More News on the Benefits of Hyperbaric Oxygen on Stem Cell Generation

It used to be said in medicine that if you understood diabetes you understood medicine.  The reasons we said that was diabetes adversely effects everything in the human body. In addition to the damage elevated sugar has on proteins (glycosylation), it impairs tissue blood supply by damaging the tiny capillaries.  We’ve known for a long time and certainly at my Hyperbaric Centers we have observed this first hand over and over again – that HBO rapidly causes healing.  And it isn’t just because oxygen was needed by the ailing tissues. One of the important effects of HBO is to mobilize stem cells from bone marrow.

When added to the study I referenced yesterday that demonstrated stems cells plus HBO were superior to either alone – we can see a path for healing chronic diseases – and just diabetes.  It is likely this combination of HBO and Stem Cells can benefit many if not most chronic illnesses as well as acute injuries.

Here is some more research published this week.

Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: Increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy.

Wound Repair Regen. 2011 Mar;19(2):149-161.

Thom SR, Milovanova TN, Yang M, Bhopale VM, Sorokina EM, Uzun G, Malay DS, Troiano MA, Hardy KR, Lambert DS, Logue CJ, Margolis DJ.

Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, Department of Emergency Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, Department of Underwater & Hyperbaric Medicine, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Istanbul, Turkey, Podiatry Surgery University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, and Dermatology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania.


Diabetic patients undergoing hyperbaric oxygen therapies (HBO(2) T) for refractory lower extremity neuropathic ulcers exhibit more than a twofold elevation (p=0.004) in circulating stem cells after treatments and the post-HBO(2) T CD34(+) cell population contains two- to threefold higher levels of hypoxia inducible factors-1, -2, and -3, as well as thioredoxin-1 (p<0.003), than cells present in blood before HBO(2) T. Skin margins obtained from 2-day-old abdominal wounds exhibit higher expression of CD133, CD34, hypoxia inducible factor-1, and Trx-1 vs. margins from refractory lower extremity wounds and expression of these proteins in all wounds is increased due to HBO(2) T (p<0.003). HBO(2) T is known to mobilize bone marrow stem cells by stimulating nitric oxide synthase. We found that nitric oxide synthase activity is acutely increased in patients’ platelets following HBO(2) T and remains elevated for at least 20 hours. We conclude that HBO(2) T stimulates vasculogenic stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds.

IF YOU NEED INFORMATION ABOUT HYPERBARIC OXYGEN YOU MAY CONTACT:  or ICDRC in Florida  (321) 259-7111 or CIHC in Irvine California (949) 428-8878.

About Dr Bradstreet
Dr Bradstreet is a graduate of the University of South Florida College of Medicine and received his residency training at Wilford Hall USAF Medical Center. He is a Fellow of the American Academy of Family Physicians. He is an Adjunct Professor at the Southwest College of Naturopathic Medicine in Arizona. He is extensively published in the peer-reviewed literature on subjects of autism, oxidative stress, mitochondrial disorders, virology, hyperbaric oxygen, and toxicology (especially heavy metal chelation). He is trained in the the isolation and use of stem cells.

2 Responses to More News on the Benefits of Hyperbaric Oxygen on Stem Cell Generation

  1. Doron says:

    Hi Dr Bradstreet,

    The following link suggest that ROS also involved in the repair mechanism of the stem cells.

    Neural stem cells maintain high levels of reactive oxygen species, UCLA study finds:

    Maybe it is reasonable to cease treatment with antioxidants during the HBO treatment that follows the stem cell transplantation?

    Maybe adding Arginine to increase NO->NOS ?

    Or in general the brain should be left in it’s worst condition with lots of chemokines,ROS,RNS
    for the stem cells reach their full potential?

    • It is a an interesting question. The inner working of stem cells in the brain is still poorly understood. However, short term exposure to free radical activity (oxidative stress) is a good message to the body to repair itself. This is a major reason HBOT works – it signals to the body to repair and liberates stem cells as part of that process. i doubt the brain has more than short term tolerance for oxidative stress.

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