Application of Cell Therapy for Autism Spectrum Disorders and Related Neurodevelopmental Disorders: a call for papers

The new year starts out with Hindawi Publishers (Stem Cells International) seeking to expand the scientific literature on a complex and controversial aspect of autism potential therapies – stem cell therapies. I was pleased to be asked to be a guest editor for this special issue. 

Here is the full call for papers and the link to the website. If you are a professional working with cell therapies please consider submitting a manuscript for consideration. 

Call for Papers: Stem Cells International

Autism spectrum disorders (ASDs) are heterogenous neurodevelopmental pathologies characterized by impairments in social interaction and communication and by restricted, repetitive, and stereotyped patterns of behaviour. Commonly, the symptoms are apparent before 3 years of age. Together with other related neurodevelopmental insults, ASDs have been recognized as a major public health problem. Prevalence rates for ASDs are increasing rapidly. The lack of specific biomarkers for diagnosis provides challenges for disease monitoring and hampers therapeutic selections. There are currently no approved treatments for the underlying pathophysiologies of ASDs. Psychopharmacological interventions provide partial relief for only some dysfunctional behaviour. Currently available therapeutic strategies for ASDs can be divided into behavioural, nutritional-biomedical, and pharmacological therapies. Cell therapy represents the great promise for the future of molecular and regenerative medicine. Several types of cells offer a valid approach to curing several untreatable human neurodegenerative diseases. Based on recent advances in the understanding of immunological pathologies associated with ASDs, it appears that cell therapies could be designed to target the observed molecular mechanisms of these disorders. We invite authors to contribute original research articles, as well as review articles, that will focus on the novel findings on molecular, biochemical, and cellular basis of ASDs to provide scientific rationale for cell and stem cell applications. Papers describe new insights into ASD using animal models and potential stem cell clinical applications are encouraged. 

Potential topics include, but are not limited to:

Recent insights in ASD research

Identification of potential ASD biomarkers

Recent advances in animal models of ASDs

Potential therapeutical application of cells in ASDs

Rationale for a possible use of several types of cells in autism-related psychiatric disorders

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/sci/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/sci/asds/ according to the following timetable:

Manuscript Due Friday, 10 May 2013

First Round of Reviews Friday, 2 August 2013

Publication Date Friday, 27 September 2013

Lead Guest Editor: Dario Siniscalco, Department of Experimental Medicine, Second University of Naples, Caserta, Italy

Guest Editors

James Jeffrey Bradstreet, International Child Development Resource Center, Cumming, GA, USA

Chen Lin, Department of Neurosurgery, Beijing Rehabilitation Centre, Beijing, China

Alessio Fasano, Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, USA

Autologous Stem Cells plus Platelet Enriched Plasma for Degenerative Knee Disease: Immediate Relief of Pain Reported

This story comes directly from the patient’s communication regarding her outcome from adipose derived stem cells with PRP (platelet factors) for her degenerative knee disease. First, a little background: we are talking about a 49 year old mother of child with autism, whose husband is stationed in abroad. For 14 months she has been in moderate to severe pain in her right knee.  She had an injury when her autistic child fell on her knee damaging the meniscus and the medial collateral ligament of that joint.  Following surgical removal of the damaged portion of the meniscus she had pain so bad she was getting to the point of accepting her orthopedic surgeon’s suggestions to do a total knee replacement.

Think about that for a moment: mother of a child with autism having major joint replacement surgery while her husband is in Japan.  Rehabilitation from that surgery is painful and protracted. 

So, we discussed the option of using her own adipose (fat) derived mesenchymal stem cells, combined with her own platelets in an attempt to prevent serious surgery.  She was already familiar with stem cells after using them for her child. But those stem cells were only available in Ukraine and their techniques were not joint specific treatments.

We discussed the options available and she decided self-donated stem cells made the most sense.  She required only local anesthesia and drove herself home after the procedure. Immediately prior the procedure we used hyperbaric therapy at 2.2 ATA to increase the stem cell yield (based on previously published literature). Here are excerpts of several emails being posted with permission.

FRIDAY: DAY ONE – A few hours after the procedure.

Hi Dr. B,

I had bumper-to-bumper traffic nearly the entire return trip home in Friday frightfest rush hour, so I finally got home a bit after 7 PM and received your message.

I had no pain or problems driving with regards to my tummy or knee.  Since I’ve been home, my tummy has been oozing some more liquid but there is no soreness or bruising.  I’m still a bit white in the injection area but I have full feeling with no numbness.  As for my knee, I don’t feel any significant pain; I would describe the pain more as stiffness and minor soreness.  You were able to get a good deal of stem cells/PRP into the swollen problem area from my surgery (which we saw at the office) — the area still has fullness there. (She went into the lab with me as we isolated the cells so she could see the yield from the small amount of fat we removed.)

So, I’m doing great with the worst part of the procedure being the drive home!   THANKS SO MUCH for doing the procedure for me.  Let’s hope for the best — I want to avert a knee replacement for as long as I possibly can!”

SATURDAY: Day 2.

“Hi Dr. B,

I’m still doing good with the only pain (minor) that I have is the incision above my belly button where you inserted the cannula.  The “poke” marks around that area are now visible (pink/mildly red) but don’t hurt.  I’m still a bit stiff but not sore around my knee so all is well!  I’ll keep you posted and we’ll see you in a couple of weeks!”  The poke marks are where I inserted a combination of dilute salt water with anesthetic.

MONDAY: Day 4.

“Hi Dr B,

You’ve given me a great birthday present today — to be nearly pain-free in my knee for the 1st time in 14 months since I tore my meniscus and had subsequent surgery.  I had recently scheduled an in-office appointment with you on Monday the 17th for my son in case he neededit, but he’s doing great, so we’ll only need to discuss the next steps for my knee.

I still have the instability issue that we discussed and limp due to the tightness that developed following surgery last December.  But, I’m not sure whether I limp because I’ve been doing it for so long that I need to re-train myself to walk correctly.  I’ll be setting up one of my husband’s indoor bike trainers to begin exercising my legs regularly to help address the tightness issues and strengthen my leg which I’m sure will help.

In regards to my tummy, the soreness is now virtually gone except for some tenderness at the incision point, which has sealed nicely.  I think the most “painful” (which was only a mild soreness) part of the procedure was the liposuction.  The injection into my knee area was only momentarily painful a couple of times, but otherwise, the injection and afterwards was not painful or sore for me.  Prior to the procedure, my knee pain had become so bad that I was on the verge of acquiescing to my ortho’s strong push for replacement — glad I didn’t do it!

FYI – Should you be interested, the GA Aquarium gives residents free admission on their birthdays, so I’m treating myself to a day there.  So, we’re off !”

TUESDAY: Day 5.

We talked on the phone so I don’t have an email to insert, but the conversation went like this. Despite spending the day walking at the Georgia Aquarium she had minimal discomfort.  Prior to the stem cells she admitted she would have been miserable. The minor outpatient procedure took about 4 hours total and was obviously easy.

No one can predict how long this procedure will help her, but for know at least she is happy to not have had major surgery and to be able to easily care for her child’s special needs.

This is what she has at least for now avoided. Knee replacement surgery is a major procedure.

http://healthpages.org/wp-content/uploads/2010/06/knee-replacement-surgery.jpg

The next step for her will be to use a simple process to improve stability in the medical ligament complex.  Eventually, we may use some additional self-donated stem cells to enhance that recovery process as well.

Back from Europe with Lots to Share

After 10 days in Europe with several of my research collaborators I have lots to share.  Right now I am still jet lagged, but I will share my observations in the next few days.

In the meantime, enjoy some of what I enjoyed.

Punting on the Cam River (as in Cambridge) [punt means boat for you non-Brits)

Kings College in Cambridge

Kings College Chapel

IMG_0604

Enjoying Hamleys Toy Store in London

Brunel Lecture

Before Lecture at Brunel University with Treating Autism Trust

Westminster

Westminster and Parliament – London

Aaron Paris Airport

Aaron’s version of sensory integration at Paris Airport.

Aaron McD Kiev

Ok its McD’s and normally I am not a fan, but in Ukraine the quality is much better and even the ketchup has no high fructose corn syrup – although we brought our own organic ketchup.  Generally the food quality is Ukraine is incredible – especially fruits and veges.

Working with my colleagues at the GcMAF production center in Europe.

More parent observations on the combined benefits of GcMAF and EmCell stem cells.

The hardest thing to do as a parent of a child with autism is to keep trying and to not lose hope. The following story is also available at www.Marilynfundraising.org. I asked if it was ok to post and her parents agreed to share the information with all of you. Marilyn Rose is now almost 6 and in April, 2012 she had her first course of EmCell therapies using fetal derived stem cells.  She was a tough kid to get response from and at 5 plus years old she essentially had no language and was in her own world.  With persistent parents who refused to give up the family put together the funds to get stem cell therapies and to provide GcMAF at low doses to support her immune system.  The combination (persistence, GcMAF, and Stem Cells) is paying off. Here is her story.

Hi Valentino and Dr. Bradstreet,
We are very excited to give you Marilyn’s more recent update.  When I last wrote EmCell in May, we were thrilled because Marilyn was imitating vowel sounds with prompting (after having a baseline of mostly nonverbal, only speaking a word every few months).  Marilyn has developed so much more since May!!

Marilyn now repeats any and almost all words, and this month has started with spontaneous speech and singing!!  She is now fully potty trained and brings herself to the bathroom independently to use the restroom.  She uses utensils with all meals (pre-stem cell treatment she had using a spoon on her therapy plan for a year and without making any gains).  She also learned to swim in the past 2 months.  She shows such a deeper level of thinking now, as an example, she will pick out her own clothes and is even starting to dress herself independently (she never showed interest in clothes before treatment and would not assist in dressing herself).

We are so happy to see such progress for Marilyn and are so thankful to EmCell and Dr. Bradstreet for helping us get this far.  We are also excited to see what the upcoming months hold for her.

We just finished a week of Dolphin Therapy in Key Largo and have applied for horse therapy next!!  I’ve attached two of Marilyn’s pictures from her time at Island Dolphin Care.

 image

Thank you for all of your help!!
Heather

Contrasting Stem Cell Options in Autism

Picture: Neuronal (brain) Stem Cells

I’ve written a lot about our possible stem cell options on this blog, for Autism Science Digest and even chapters in scientific books, but nothing contrasts and compares our choices like the real world experiences of our children.

The young man I will present to you next is currently 12 years old. He had a prior history of autoantibodies to his blood vessels and had proven to be only slowly responsive to a wide variety of therapies when it came to spontaneous language.

In September of 2011 he had autologous (his own) stem cells harvested from his adipose and re-implanted in a clinic in the Dominican Republic.  This did seem to help his GI issues and calm his food allergies.  It did not result in changes in his language.

After his stem cell implant in the DR, I suggested we measure nagalase activity (viral protein marker) and it cam back elevated.  We started GcMAF to prepare his body for a second round of stem cells.  However, after his first course, his parents heard a lecture of mine on Fetal Stem Cells and the differences they presented over adipose (fat) derived stem cells.

They elected to pursue stem cells at EmCell in Ukraine. My logic was simply this; fetal stem cells create the growth factors and signals a child’s existing stem cells (living in his own brain) need to activate and then to potentially repair his brain.

The following email came from the child’s mother about 3 weeks after fetal stem cells were transplanted at the EmCell center in Kiev. After reading this, if you are interested in more information please contact my office and we can find time to discuss this further. 

FROM HIS MOTHER

hello everyone,

i contemplated on waiting for “more remarkable” improvements before posting my first update but a lot you have emailed and called….. so i thought to myself, these may be small improvements, but to other parents who have severely autistic children, these are major feats for them. some of you are on your way to EmCell treatments for your kiddos to so here you go!

1. He was able to tolerate sightseeing for hours and hours. after 2 days of Stem Cells (SC), we had time on the 3rd day to walk around kiev. matt walked a total of 3.5 km in a span for 5 hours. i couldn’t walk back another 3.5 km so we grabbed a cab back to our hotel. even at disneyland, we would have to get him a jogger stroller because he doesn’t tolerate walking for a long period of time.

2. in madrid, on our first night, our friend served jamon iberico (very thin sliced cured ham). obviously this is room temperature. for the first time ever, he didn’t request for microwave (his food has to be steaming hot and drinks have to ice cold) and ate a lot (and i mean a lot!) considering this is the first time he’s seen this. My son doesn’t eat food that he’s not familiar with, more so that it’s not hot. but he did!

we had 2 full days in madrid and would leave at 12:30pm, get to the restaurant for lunch 2:30-5:30, sightseeing for another 3 hours, dinner at restaurant 8:30-11:30 and get back to our friend’s place past midnight. the temperature here was 108 deg, matt is able to sit for 3 hours of lunch without his ipad (no wifi) and still walk for sightseeing under the heat! then sit for another 3 hours at the restaurant for dinner, by 10:30, he’d be all yawning but was game enough to sit until dinner is done by 11:30. he wasn’t tired or anything, i was tired because of the extreme heat and humidity. any child that will sit down for a 3 hour lunch or dinner would be bored to tears but not matt! except for a few whinings here and there but redirectable, he was really well behaved! and ate foods that he’s never had in america!

3. the whole week this week, he started cooking camp monday and went back to school on tuesday (which was his 12th birthday as well) morning and continued cooking camp in the afternoon. his whole demeanor has been happy in general. his academic performance at home with his lovaas therapist for 2 hours at home has been well, he is much, much faster in finishing up his math and comprehension worksheets without any whinings (okay, so his sched mon-fri 9-12 school, 1-4 cooking camp, 5:30-7:30 lovaas therapy at home) considering he’s had a whole day of activities.

4. yesterday morning in bed, dad was tickling him. he normally would say no tickle, i don’t want tickle. i was surprised when i heard him say “i don’t want TO BE tickled” the grammar and sentence structure was just perfect! i had to say what? and he repeated it, exactly the same. and then he said, “i want to blanket”. i corrected him by saying i want to USE blanket. he then points to the folded blanket above my head and says again, “i want TWO blanket” meaning he wants the 2nd blanket over the blanket he already has! he said it right and mom was wrong!

5. yesterday, he finished his stewed eggplant. a first! it kinda looked yucky to me….. but he finished everything! and he went to the park with his respite aid yesterday from 11-2 in the sweltering heat of 100 degress! his aid said he enjoyed playing on the swings, slides, he has never enjoyed going to the park. all he wants to do during weekends is go to the mall or cvs or target and go to the shampoo/lotion section to smell, smell, smell.

6. today, we had lunch at my uncle’s thai bbq restaurant. so all the food is already on the big table (buffet style) and everybody has started eating. he kinda looked like he was waiting for something, and he got his plate and sat by the table where all the food was in front of him. everybody was already eating and i guess since his favorite (and the only dish he would eat there) was still missing, my uncle jimmy (his grand uncle) asked him, what are you waiting for? he actually responds by saying “garlic short ribs”, i was surprised. coz he never responds to questions asked of him other than myself, yaya, dad or his therapists/teachers.

and normally too, once the garlic short ribs is served, he will NOT, ABSOLUTELY NOT, share with anyone else. if anyone gets a piece, he will get mad and start whining. well, today, i told him to get only 2 pieces and put the dish in the middle together with the rest of the dishes. he was fine. i told everyone to get, and people were asking maybe he’ll get mad and throw a fit. i asked him gently if it’s okay for other people to get, he said yes. and it was really fine! and he also ate another new dish.

7. lastly, we went malling today with my sister, we didn’t take him to bath and body works or victoria’s secret, he asked but we didn’t. and he was totally fine….. just so you guys understand, my son has a fixation with smelling. so a trip to the mall is not complete without going to those 2 stores. he was totally okay hanging out with us while we walked around for 3 hours.

so this is it for now. i really hope to share “miraculous” improvements soon. i know i have to patient, the EmCell doctors told us to wait 2-3 months to see the full effects of the stem cells, to give them time to grow.

i hope you all can continue to pray for his miraculous progress and hopefully on my next update, i will have “remarkable improvements” to share!

as always, i have to Thank God, for this opportunity for my son. and to put my trust in God that He will heal my boy, in His time, in His way, and according to His plan! I have to be faithful – AND LEAVE THE RESULTS WITH GOD.

P.S. i just have to add this, i was tucking him in bed just now, and he asks to watch cooking.  so i turn on the tv, etc, etc.  i put the blanket over him, and we have this conversation:

him:  i want massage please

mom:  where?

him:  head please (he puts his hands on his head)

mom:  okay (i put my hands on his head)

him:  healing, go back ukraine, healing.  doctors, healing.  autism be okay.  jesus heal autism

mom:  wow matt!  yes, you will be okay

him:  go back fabio hotel (our friend’s place in madrid, fabio is the son’s name, he thought we stayed in a hotel)

this whole exchange was spontaneous, no coaching, so out of the blue. 

all i can say is praise God!  more stories to share in Jesus’ name!

What’s Wrong with the Gut of Children with Autism?

At its core, autism, with all its bizarre behaviors, poor language, social isolation and delays in development, might come down to an altered intestinal ecosystem.  That possibility was expressed by Professors Finegold and Borody [below] (and others) at the GI Think Tank at the Autism One conference in Chicago last month.

Borody and Finegold

I remain cautious about this perspective, but it has a fair chance of explaining some of the refractory and significant issues our children present us.  In a healthy gastrointestinal ecosystem there may be more than 5000 different species of bacteria present. That diverse ecosystem provides a stable foundation for the development of the child’s immune system (Gut immune maturation depends on colonization with a host-specific microbiota. Cell. 2012 Jun 22;149(7):1578-93. Chung H, et al. Harvard Medical School, Boston, MA 02115, USA.). But it isn’t just the GI immune system -70% of the total human immune system is gut related.

Sadly, for most children, no probiotic or antibiotic intervention provides sustained healing of the gut ecosystem and this includes: specific carbohydrate diets, paleiodiets, raw camel milk, kefir, biofilm protocols or pounds of probiotics per year.

In contrast to a healthy gut, evidence from sophisticated DNA probes is telling us the autism ecosystem may be hanging around 300-500 species (a fraction of normal 5000 species). So it is biologically impoverished and with that species which would normal get a small piece of the metabolic impact of the gut, actually dominate the biochemistry and immunology. Therein lies the problem: altered ecosytem = altered biochemistry = altered immunology.

Now, more about probiotics and diet.  Many of you have spent $$$$ on special diets and probiotics and are largely where you started: poorly formed, foul smelling, weird colored bowel movements or stuck with chronic constipation.  After putting more thought into this, we shouldn’t be that surprised by the often poor results from both diet changes and probiotics.  The ecosystem of the gut is diverse and complex.  It is also specific to its anatomy.  Higher up in the mouth, esophagus, stomach and small intestine, species that can tolerate more oxygen in their environment are favored.  Lower down in the large bowel or colon, species that do not tolerate as much oxygen (anerobes or partial-anerobes) do better.

Probiotics are nearly exclusively aerobic (oxygen-liking) species. This simply means they would prefer to grow closer to the mouth, including the small intestines. Small intestinal bacterial overgrowth (SIBO) is a likely consequence of giving aerobic bacteria (probiotics) to a child, especially when we know sugars are more poorly digested in the autism gut.  (see: Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. Williams BL, Hornig M, Buie T, Bauman ML, Cho Paik M, Wick I, Bennett A, Jabado O, Hirschberg DL, Lipkin WI.  PLoS One. 2011;6(9):e24585. Epub 2011 Sep 16.).

But at their best, probiotics, allow you to supplement just a few species: likely several thousand species less than the natural diversity of the human gut microbiome.  Without that broad ecological stability, the immune system gets pushed around far more than desirable.  The results are food allergies, irritable bowel (cramps, diarrhea and constipation), overgrowth of potentially toxic bacteria, and inflammation both in the gut and more widely in the body (eczema, asthma, and rhinitis). Further, the biochemistry of the gut microbiome, which is typically 50% of a person’s total metabolism, will shift dramatically.

All that is left is to explain how this ecological impoverishment of the autism microbiome, creates neurodevelopmental dysfunction. And this is where a whole bunch (nearly all) of psychologists, neurologist, and pediatricians struggle to see the connections. To be fair to their skepticism, the potential link between the gut microbiome and neuroimmune problems are just beginning to emerge in the medical literature.  (Immune and neuroimmune alterations in mood disorders and schizophrenia. Drexhage RC, Weigelt K, van Beveren N, Cohen D, Versnel MA, Nolen WA, Drexhage HA. Int Rev Neurobiol. 2011;101:169-201.) and (The mind-body-microbial continuum. Gonzalez A, Stombaugh J, Lozupone C, Turnbaugh PJ, Gordon JI, Knight R. Dialogues Clin Neurosci. 2011;13(1):55-62.).

However, even this eloquent model of human immunological development leaves out at least one critical step, which in my view separates autism from kids with food allergy, asthma and irritable bowels, but whom don’t have autism. This missing factor seems to be intrinsic immune activation in the brain of children with autism. 

The brain is very much like this castle. It has a barrier around it (the blood-brain barrier- BBB) just like the moat and drawbridge.  Each gate is design to only allow entrance to the king’s invited friends – in an ideal world that is the way our brain works – only allowing acceptable molecules access to the brain side of the BBB. 

Clearly the BBB is not as protective as it needs to be in autism, and it also appears the gate keepers (astrocytes and microglia) have even been bribed to work against the King (autoimmunity).  I still think this process of breaking down the castle/brain defenses is the work of a chronic pathogen (likely viral) residing in the endovascular compartment – which is the BBB.  This is where I think GcMAF is helping to correct the persistent issues (please see prior posts). 

But we need to get back to the gut ecosystem and explore what the medical literature is telling us about repairing that environment.

First, it is finally becoming more mainstream to think of fecal bacteriotherapy (FBT) or transplantation as the ONLY way to replace the missing good bacteria.  The shortcomings of traditional probiotics are clearly evident (ie, aerobic and few in diversity). FBT simply means giving health feces to an unhealthy person to make them healthy.  Sound ridiculous? It isn’t and it may be an inexpensive fix for a complex biological condition.

Finding a donor for providing an ideal ecosystem transplant is very challenging. Here are a few of the proposals for screening potential donors present in the medical literature.

The Australian CDD criteria:

image

Borody and Khoruts: Nat Rev Gastroenterol Hepatol. 2011 Dec 20;9(2):88-96.

Unfortunately, if you read the list of exclusion from Borody and Khoruts you will quickly realize there are few potential donors left within your family or circle of friends.  That is a a real problem.

Harvard proposed a somewhat easier protocol for screening the potential donors for acceptable criteria.

image

Pediatrics. Russell et al. 2010 Jul;126(1):e239-42. Epub 2010 Jun 14.

I tend to favor the Harvard protocol as it is more specific, and yet I do think we need to screen the donor’s gut history as well. 

This is the Harvard treatment protocol.

image

image

The Harvard protocol is fine if you have access to a hospital willing to work with you, or at a minimum, an out-patient center with x-ray and other equipment.  Others have suggested colonoscopy (surgical procedure), but again the risks benefits get harder to sort out.

Practically speaking – there is NO WAY this will be happening for autism: so I propose a modification of the current techniques being employed for FBT.

The Bradstreet Protocol for FBT in ASD :

1). The child’s family initiates screening of donors within the family and close friends. These individuals, if willing, will have more formal screening. First, however, the family should find donors who meet the following criteria:

a). Generally healthy with no known infectious diseases and with good bowel movements.

b). Limited use of antibiotics especially in last 6 months.

c). Stools are brown, formed and not foul.

d). No apparent abdominal pain patterns.

e). No obvious food allergies.

f). Not using heartburn medicine.

g). No significant food cravings: donor eats a diverse diet, including vegetables.

2). Once a list of potential donors is identified by the family, a short interview with the treating physician needs to take place to review history related to antibiotics, risky personal behaviors and medical issues.

3). Individual potential donors who are not excluded should then undergo medical screening to rule out:

a). Hepatitis A, B and C

b). HIV 1 and 2

c). Syphilis and Lyme disease

d). H. pylori

e). Fecal parasitology and culture or,

f). Comprehensive Stool Digestive Analysis 2.0 (Genova Disgnostics)

4). Once a healthy donor is identified, the process of preparing the child to receive the donation begins.

a). Prep the bowel just as required for colonoscopy (GoLYTELY®, Magnesium Citrate, X-prep®, enemas or other interventions to cleanse the bowel of existing feces.

b). Potential antibiotics (vancomycin, Xifaxan, etc), antifungals and anti-parasitics for the recipient.

c). Gather fresh feces from the donor and rapidly place 1 cup or less in plastic freezer bag with 250 -500 ml of sterile salt water (saline) and express excess air so as close to all air is removed as possible.

d). Mush the feces and water until it is a slurry or puree texture. Unlike Harvard I DO NOT RECOMMEND BLENDERS. They whip too much air into the donation and can change the microbiome.

e). Instill the slurry of fresh feces into the rectum via a retention enema and attempt to move the transplant to the right side of the colon. Massage the feces from the left lower abdomen up and to the right. Attempt to position the child in a knee chest – buttocks up – position and then after 5 minutes (if possible) move to a right down posture to gather the donor transplant to the right side.

f). Some children may require sedation. A bathtub may be a good location to attempt this. Consider a colon cleansing center for this procedure if you can get cooperation from them.

g). Leave the donor feces in place as long as possible before expulsion. 30 minutes is probably ideal but I realize this is unlikely. We can only do what we can do.

ALL of this requires physician supervision.

I Hear You: Traveling into the Mind of Autism and the Siblings Who Love Them

Recently, at the Autism One conference in Chicago, Virginia Breen, the mother of a 14 year old girl with autism introduced me to the audience. “Ginny” is an amazing mother.  Her daughter does not speak, but she does use keyboards to communicate, so she collated her daughters written poetry into a book called “I AM IN HERE”.  During my talk, now known as: “The Ruby Slipper Lecture”, I used Dorothy’s experience in the Wizard of Oz to help everyone understand what in incredibly exceptional event takes place as a child is taken into the World of Autism. In that lecture I told everyone that I have met some incredibly mean and nasty people – people who cannot think about helping children with autism – much like the Wicked Witch.

but then at the same time my journey with autism has been filled with amazing people – wondrous adventures in a way that has taught me so much about the love parents have for their children and more about medicine than I ever imagined. 

In that way, I am on the yellow brick road with dear and trusted friends.

Most of whom have no idea just how wonderful they are, nor how much they teach me about life.

Elizabeth Bonker (Ginny’s daughter) is clearly the Scare Crow, the Tin Man and the not-so-cowardly Lion all in one (with a special touch of Dorothy just trying to get out of Oz, so she can go Home). Here is an excerpt from her book in Elizabeth’s own words:

Me Revisited

I can’t sit still

What’s wrong with me?

My body is doing things

I can’t explain

My dignity I am trying to maintain.

People stare at me

When I rock and shake.

I don’t know how much

More I can take.

So much to deal with

Going on inside me.

I wish I could get better.

I want to be set free

From my silent cage.

Then she wrote this: “Some of the people at school who do not know me make me feel uncomfortable. They stare at me. I would not rock and shake if I could stop it. It just happens sometimes. I wish they could understand, but mostly I wish I could explain it to them.”

But my journey is connected to so many others that sometimes I just have to share the love that comes my way with others.  This next piece is from Ensley; a not yet 11 year old who told me she is too old for dolls.  I believe her.  Having a brother with autism has matured her is amazing ways. She read Elizabeth’s book and wrote this to her.  Her parents shared it with me and and after a few tears I asked Ensley if I could post in on my blog, thankfully she said yes.

I HEAR YOU – from Ensley

Dear Elizabeth,

I love your poetry, it is truly beautiful. I think you are amazing because even though you cannot speak with words, you find a way to express yourself in ways that mean more than words. Your poetry is special because it proves to everyone that even people who cannot speak, have a voice.

I feel I understand the struggles you write about in your poetry because I have ADHD, and my little brother has autism.

Before I knew that it was my ADHD and sensory problems that caused me to behave differently than other children my age, I always felt there was something wrong with me. I felt left out, alone, and abnormal. Some days, I feel very out of control, like I am spiraling through a dark, endless hole with nothing to grab onto, and no one to stop me from falling.

I know my little brother can understand how it feels to seem so different from other people. When he is mad or frustrated, he starts hitting his head and stomping on the ground because he cannot find the words to tell us what is wrong.

Like you, I understand what it is like to be stared at. Sometimes my brother gets mad when we are out in public, and throws a tantrum. There have been times when people will look at him like he is a circus act. I wish those people could try and understand what it’s like to be in my brother’s shoes.

Even though disabilities like autism can feel like a cage, prohibiting you from spreading your wings, you do not allow it to, and I admire that greatly.

Keep writing your wonderful poetry. You are an inspiration.

From,

Ensley

I started work at 7AM and it is now 8:30PM – I have many failings – time management must be one of them, but I cannot stand the idea of failing these incredible and beautiful children.  So each day I pray more more children get their ruby slippers and find their way out of Oz.  May they all be blessed.

Understanding GcMAF from the Mind of Autism

I need to hear as much from inside the mind of autism as I can.  I need to know what they feel, think, experience and how they process.  I helps me as a physician/researcher to bring them more of what THEY desire.  Scott has been my patient since 2005 – he is now 22 and in college. He didn’t speak until after age 31/2 when he started on Sporanox ® a systemic antifungal medication.

Like many children with autism he had bowel disease and needed Pentasa® a medication designed for reducing serious gut inflammation.

He also had seizure-like activity and took Depakote® a medication which is commonly used in pediatric neurology circles despite its damaging effects on mitochondrial activity.

He struggled with prosody, that quality of speech where words flow effortlessly and meter, loudness and subtlety are natural expressions of mood and intent. He had no friends and really no desire for friends.

That was 7 years ago.  Now enter GcMAF – the latest addition to his parent’s  efforts at a FULL recovery. But this is from him directly – not his parents, and that makes it ever so much more valuable.

Dear Dr. Bradstreet,

I just wanted to let you know what improvements I have seen since taking the GCMAF:

  • Hear more of conversations so asking more on topic questions and understanding the answers better
  • Better comprehension all around
  • More fluid speech
  • Speech is slower and more enunciated. Much more understandable.
  • Less cracking joints on purpose
  • Used to feel urge to shake whole body, not anymore
  • Stopped biting nails
  • Less dizziness
  • Facial and verbal emotional expressions are falling within normal ranges, esp. laughter
  • Developing interest in new things
  • Enjoying new foods
  • It seems like the brain’s pathways are finally talking to each other. Visual and auditory are being processed together to form the whole.

In addition, I require a refill on the GCMAF.

Hope all is well where you are at.

Sincerely,

Scott

Adult with Autism Responds to Fetal Stem Cell Transplantation

One of the persistent myths about autism is that unless you fix the children by 5 years of age they just aren’t going to make progress.  Dan is here to tell you that just isn’t true. Dan is now 28 years old, and he first came to my practice in 2001, as a17 year old. Like many children of his generation of autism, he presented with chronic diarrhea and the loss of language after vaccinations.  In those days, there was a lot of mercury in vaccines.  And in a sickly child with chromic diarrhea – mercury – in any amount – is never tolerated. 

His family aggressively tried everything to recover him and with that they have been tireless. Dan has struggled with seizures, esophageal reflux and several bouts of regression. He remains extremely sensitive to anything happening with his gut. Early on we found both IgG and IgM antibodies to his brain blood vessels. His urine neopterin levels were significantly elevated, and this was consistent with a chronic viral infection.

Ultimately we also found antibodies to his folate receptors and elevated nagalase enzyme activity in his blood (another marker for likely viral persistence). GcMAF completely stopped his reflux and with that we saw some important gains, but Dan was still far from being independent or recovered from his many issues.

But that wasn’t the end of Dan’s struggles.  He was also found to have a very small deletion of the terminal end of chromosome 22 (perhaps the smallest deletion measured to date).  It is compatible with an unusual condition known as Phelan-McDermid Syndrome, but a much smaller deletion than typically seen with that disorder. 

This would never be the picture you might hope for when it comes to potential stem cell therapies. Yet his parents were undaunted and any chance was enough of a chance to get their attention and interest.

After several discussions, the parents (like I had for myself and my step-son) chose to try fetal stem cells at EmCell in Kiev, Ukraine.

So a picture is worth a 1000 words and countless blessings for Dan. 

Dan on the playground

This was the first time in 10 years Dan had been able to enjoy recreation and that is truly remarkable. His parents are seeing gains in many areas and we are all truly grateful to the expertise and experience the EmCell teams brings to the treatment of autism related problems.

If you want to know more about how to optimize the outcome of stem cell therapies, please contact me (470) 253-7445, my staff have been instructed to provide as many patients as possible with a donated 30 minutes of my time to discuss stem cells. 

Parental Feedback from Experiences at EmCell for Stem Cells

I can talk all day about stem cell related immunology and chemistry and I recently did that at the Autism One – Generation Rescue conference in Chicago.  But none of the science helps parents grasp the opportunity fetal stem cells offer as much as real-life experiences of stem cell therapy actually changing lives for children. So here are three moms talking up their kids over the last 2 months. 

“I cannot thank you enough for your consult and recommendation that I take my son to Emcell.  He and I travelled there with our friends. We  have just returned from Kiev yesterday and we had a wonderful experience. Our trip went without a hitch and the doctors, nurses and other staff were amazing.  We look forward to observing results…”  – Mother of 12 year old just treated at EmCell.

“Hey Dr. Bradstreet!  I finally have good news to report!. (finally meaning 1 week after treatment).  My son is doing very well. It’s been a little over a week since he received the stem cells, but we can definitely see some changes happening. He is SLEEPING! 10-12 hours a night! Not waking up at all, it’s a restful sleep, like the covers are still tucked in. He used to sleep 8 or 9 hours and usually woke up a few times. He is calmer and stimming is way down (I’m thinking like 75%less)! It so good to see that he has more control of his body now. He’s talking more, still hard to understand sometimes, but I can tell he’s trying hard! His stutter is now only occasional instead of frequent. Behaviors are way less, he’s more cooperative and less irritable. He’s having good days! We all are! I hope these changes are here to stay and am praying for many more to come! We’ll talk to you soon! I just wanted to share my joy with you!”  – Mother of nearly 7 year old boy treat May 21-22, 2012 at EmCell.

“My daughter is going so great and we are seeing her doing something new every week.  Before her stem cell treatment in April 2012, we had not heard her say a word since before Christmas 2011.  She would average one word every 4-5 months and it was always a word she knew before she regressed (such as cat, dog, ball).  For the past few weeks she is repeating 10-12 words a day and has even picked up new words too!!  She now repeats the new words “Up, help, open” and yesterday used the word “Up” spontaneously to be picked up.  This weekend we also took her to a petting zoo and she said cow when petting a cow.  We are thrilled that her language is developing!!! 

Her other big changes that continue include her sleeping and eating well.  Before her stem cell treatment she would self-limit her food to 5 foods (chicken nuggets, french fries, chips, etc) but since the day of her IV treatment she has continued to eat incredibly well.  Before she would never eat fruit or vegetables without it being hidden in her food, now she brings us lettuce, cucumbers, oranges and other produce so that we’ll put it on a plate for her.  For sleeping, she has continued to now sleep at appropriate times (usually 9-10 pm) where before she would be up until 1-2 am and she no longer wakes during the night crying.

Thank you so much for all of your help with her.  We are finally able to do day outings as a family now that she does not have extreme anxiety issues or self-limiting her diet (that usually led to anxiety if we ran out of her wanted foods).  We have taken her to a zoo one weekend and a petting zoo the next weekend, and she did so great. She is such a happier child already and her teachers and ABA therapist have made many comments about all of her changes.  Using a spoon has been on her therapy plan for two years and she never mastered it (they even took it off of her learning plan because she was not making any progress), a month after her treatment she is using a spoon and mastered it!!  We went from not seeing her picking up any gains for the past 3 years, to watching her make a gain almost every week.  We now have hope again for her and our life as a family is now happier and easier.  We can not wait to see what the rest of the year brings for her!!” – Mother of a 5 year girl.

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