Autism Says Goodbye to 2013 and Hello to 2014: Breakthroughs and Progress

As it ended, 2013 turned out much better than I expected. I received a special present on Christmas Eve when, Itai Berger, Editor of Frontiers in Human Neuroscience, emailed me that my article on transcranial ultrasonography had been accepted and was available online in provisional format.  See abstract below.

Frontiers Abstract

This publication was the result of ongoing collaborations with my Italian colleagues at the University of Firenze (Florence). Professors Ruggiero and Pacini are pushing the immunological research in autism, chronic fatigue syndrome (ME/CFS), and cancer through their detailed laboratory investigations of the vitamin D binding protein – GcMAF. It was our shared interest in GcMAF that brought us together on the ultrasound research.  2012 ended with the publication of the first article describing Nagalase and GcMAF in ASD. (title below).

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One year later – to the day and after more than 10,000 article views – I was lecturing in Dubai at the 2nd International Conference on GcMAF Immunology.  The conference was well attended with physicians and researchers fro many countries. Pediatricians and Psychiatrists from Dubai, Jordan, Turkey, Italy, India and the US shared their experiences with GcMAF therapy in ASD.  It was very rewarding to hear their stories. They presented videos and collections of cases, all of which observed something similar to what i had already published: most children with autism respond vigorously to GcMAF and side-effects were minor and transient.

gcmaf conf dubai

I consult with families from 37 different countries around the globe and I hear the same stories about GcMAF regardless of the child’s ethnicity or culture. That likely speaks to the immunological ties between immune dysfunction and autism.  Below is one of the many extraordinary letters I received late in 2013.

Once upon a time my first born son was autistic.

       He stopped developing properly around the age of 1 and lost the few words and skills he previously had, though I don’t believe he was up to par even then. From there he slipped away from us into his own world and it was as if he couldn’t even see or hear us. He didn’t know he had a name, that we had names, or that we were even there. He didn’t babble, he didn’t play with toys, he didn’t even look up at people when they entered the room. When we had kids over to play he would hide in a corner and cry. He was chronically ill with one sickness after another, always tired, sleeping 14 hours at night and if we woke him up from his nap before 3 hours he would scream hysterically sometimes for 2 hours. The first doctor told me he was just a boy and boys develop slower, the second doc said we were just bad parents, and the third finally gave us a diagnosis at 27 months – 8 months after I had begun to worry.

     We tried everything; B-12 shots, ABA 20 hrs. a week, speech, OT, vitamin D, probiotics, and an extremely strict diet of no gluten, dairy, eggs, nuts, soy, fish, dyes, preservatives or anything artificial. These things did help a lot but even so it was an extremely difficult uphill battle of working months to gain a skill and if one person wasn’t consistent on the implantation of a goal he would regress immediately. There was a whole year that he woke up screaming every night for hours. Nothing I did helped and he couldn’t tell me what was wrong so I would resort to laying beside him and crying myself. He would wake up his baby brother who then also began screaming. It was a long year of screaming even from me! I once responded to one of his fits by having an all out screaming meltdown of my own, face down on the floor pounding the ground like a 2 year old. I was depressed, exhausted, and contemplated many times just ending it all…I have to be real because other parents need to know they are not alone in this. Besides the screaming he was always horribly constipated to the point of needing medical intervention, he had raging eczema head to toe, was allergic to literally everything; I knew my son was sick. I often told my husband, “some day 50 years from now the doctors will finally figure out that autism is a problem with the immune system but by then it will be too late for him.” I thought he would live with us his whole life and just continue to be a tired, sick, crying, itchy boy, who couldn’t get words out or look at us. Then my friend told me she found a doctor named Bradstreet who did believe it was immune related and was treating it! I had hope!          

     We started GCMAF and began seeing real progress after the level 7 dose. He seemed more energetic, cried less, and speech and eye contact were improving. Each week began to be amazingly better than the last and it felt like we were seeing actual recovery. Then after about a month he ended up in the hospital with a raging sinus infection of strep that led to an abscess behind his eye. This is a very rare complication but as I said, he had the immune system of a flea. He needed emergency surgery to save his eye but continued to battle the infection and a fever of 104 for 11 days until they resorted to surgery again, this time fully removing his right ethmoid sinus.  During his hospital stay and for 3 weeks after while he was still on antibiotics we couldn’t do GCMAF. His regression was significant. His speech went way back to about 9 months before we started GCMAF, he could only get a few words out at a time with great difficulty and even I couldn’t tell what he meant. He actually said to me finally, “mommy. help me,” and I said, “with what baby?” He struggled to get out the following, “with the…words…not come….out… good.” I cried because I knew he felt trapped in his own body unable to do what he was trying to. When I told him the shots were going to help him be able to speak he was eager to get them and reminded me every week on Wednesdays.

     When we started back up again and finally got the progress going he developed a rash which I now know was molluscum but at the time thought it could be related to GCMAF. We changed his dose from the level 12 once a week to level 5 twice a week and then we lost him. He went off into “autism-land” as I call it. Didn’t hear us, couldn’t focus, couldn’t even accomplish a single step direction and wandered around aimlessly. This dosage was working for other kids but not for him. We went back to level 12’s once a week and after 6 weeks of that he was in everyone’s mind effectively cured.

     His speech and OT discharged him, and after 2 weeks of being in a typical kindergarten class with no aid, the school coordinator told me he didn’t even need any special accommodations. We increased his school day to be full day now from 8:30-3:30 and even though he isn’t even 5 yet, there are zero problems. Zero. No fits, no meltdowns, no non-compliance. His teacher told me he listens in class, follows the schedule with no extra prompting, plays with kids on the playground, holds his pencil properly (big one!), and even sits with friends asking them where they live and what they ate for snack. After school he is able to tell me what he did, describe details about movies or books they read, sing me songs he learned, and he still has energy to play and doesn’t melt down when we get home. He never previously had the skills of recalling events or asking/answering questions properly until this. He currently has no therapy and we see no autism in him whatsoever. He says what he wants when he wants fluently, uses slang terms and laughs at jokes! He has even developed a little bratty back-sass attitude which my husband and I correct but then turn to each other and cry happy tears because it’s SO normal!! He was actually able to tell me that he likes the shots because his sleep is better, he has more energy, and he can speak better. He also hasn’t gotten sick once since the hospital stay back in March. His bowels are no longer dependent on laxatives daily as they were for 2 years. It’s like a dark cloud has been lifted and my son has been freed from his internal prison. We have the son we never had but knew was in there somewhere dying to get out. I have no doubt he will live a normal life and accomplish anything he wants to from now on. I don’t know if he will need GCMAF permanently or not but even if he does I don’t care. I will never let him go back into that cave. I firmly believe God answered my prayers and healed my son and he used Dr. Bradstreet and GCMAF to do it. Our son is healed and so is our family.

Forever indebted and grateful beyond measure,

His Mom

As a parent (and I am one with 2 boys, my own son and my step-son are both on the autism spectrum) these stories are powerful and touching.  But as a scientist I am driven to understand the mechanisms behind these types of anecdotes. The story relates a child rapidly changing state from significant and non-verbal autism, to observed to be normal by parents, teachers and therapist over a mere few weeks.  Autism has been felt to be a developmental and irreversible brain disorder. Clearly that is not always the case, as many stories of recovery are being published in the lay literature.

So how can this happen?  Mechanistically, I think this must represent the presence of an interfering inhibitor to normal neurological functioning. Whatever this substance or effect is, it acts very much like local anesthesia blocking signals in specific parts of the brain. In at least the example described above, that effect is then rapidly dissipated and the brain essentially wakes up. This story is common and doctors at the conference in Dubai presented their own versions describing very similar events in their practices as well. But not all children respond to GcMAF and that speaks to various subtypes of the disorder, some of which are readily recovered while others seem much more entrenched in whatever autism represents at the brain level.

It appears a significant subset of autism is immunological driven and that would fit the observations noted from around the world regarding GcMAF as a therapy. The graphic below is from a review article: Gesundheit B, Rosenzweig JP, Naor D, Lerer B, Zachor DA, Procházka V, Melamed M, Kristt DA, Steinberg A, Shulman C, Hwang P, Koren G, Walfisch A, Passweg JR, Snowden JA, Tamouza R, Leboyer M, Farge-Bancel D, Ashwood P. Immunological and autoimmune considerations of Autism Spectrum Disorders. J Autoimmun. 2013 Aug;44:1-7. doi: 10.1016/j.jaut.2013.05.005. Epub 2013 Jul 15.

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IN the graphic the authors depict the maternal immune system with its macrophages and other immune cells priming the response of microglial cells in the fetus.  Microglial cells are derived from macrophages which migrate into the brain during fetal development.  Those macrophages then undergo changes to become microglial cells.  They, however, maintain many of the features of their original macrophage immunochemistry. Missing from the diagram is another intersect circle representing the postnatal environmental effects. But regardless of that limitation in the representation, the hypothesis they propose is chronic immune – inflammatory changes in the brain secondary to microglial swelling.

GcMAF as noted in my paper, stands for Gc protein macrophage activating factor.  That name makes it sound like a pro-inflammatory molecule and as such based on the model above it would seem to be the last thing you would want to give to a child with autism.  As it turns out, the argument for chronic inflammation in the brain of children with autism is not universally agreed upon and other researchers, particularly Prof Manuel Casanova, have the opinion there is no inflammation in the autism brain.

I had the pleasure of sitting with Prof Casanova at several autism-related think tanks where the immune system was being discussed.  He took a decidedly differing view that there was no evidence of inflammation in the autism brain, but rather there was abnormal construction of the brain’s special electronics and at its smallest unit the minicolumn.  Casanova explained he had dissected scores of brains in great detail and inflammation was not present.  Instead the consistent finding was abnormal minicolumn construction. Below is an excerpt from a complex but insightful review we must consider.

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How is it that both camps: the inflammatory and the minicolumn, can be so divided in their views of autism?  First, I agree that autism is primarily influenced by epigenetic factors. In 2013 I participated in a review of these factors which is public access.

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In this review we wrote: “The term epigenetics was first coined in the 1940s by British embryologist and geneticist Conrad Waddington, who described it as: “the interactions of genes with their environment, which bring the phenotype into being” [17]. Our present knowledge enhances this earlier understanding, and epigenetics now evaluates the alteration of DNA transcription via variations in DNA methylation and histone modifications, but without alterations in the DNA sequence. These variants represent the epigenome, which in turn will be reflected in the transcriptome: that portion of the DNA which is being actively transcribed into RNA.”  The key is the environment regulates DNA transcription (messaging) without changing the sequence (no mutations) of the DNA.

Let’s return to the original article I posted on Transcranial Ultrasonography of the Brain.  An important part of that research was the publication of this research in Brain:image

And most importantly this observation; that there was too much fluid around the brain of children with autism.

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In the figure above I excerpted the images from Shen, et al., 2013 and added the arrows and notations of increased EAF.

In our paper on TUS we observed the same effect – increased fluid surrounding the brain. Below is a side-by-side comparison of fraternal twins from our paper in Frontiers in Human Neuroscience (2014).

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Under normal conditions the fluid (hydrostatic) pressure of the subarachnoid space (the fluid surrounding the brain) is not sufficient to keep the space fully open at the point where the brain folds itself closely to the skull.  In figure 13 from our paper, you can see the space of Twin A stays constant at 0.16 cm as the underlying brain compresses the arachnoid (meninges) of the brain, whereas with Twin B the space is compressed down to 0.01 cm. Now go back to the images from the Brain study of Shen, et al., 2013. If you study those images you will see that in the neurotypical child, the gyral summits (places where the brain folds up towards the overlying inside of the skull) come is very close proximity to the inner lining of the meninges and typically seem to be touching the membrane.  In our higher magnification views we see the same effect (Twin B). However, we and Shen, et al., 2013 observe the same increased distance of fluid volume in the case of autism.

So what does this mean?  At a recent MAPS conference I pulled Professor Theoharides aside to discuss my observations.  “Theo”, as well al call him, is a brilliant Mast Cell researcher and you can pull up his publications at his website: www.mastcellmaster.com.  I will insert a portion of one article, but realize Theo has extensively published on the immune and mast cell effects in ASD.

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The graphic below is in my opinion a more complete understanding of the immune and epigenetic effects than the one from Geshundheit, et al., 2013.

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This graphic gets us closer to what I think is really happening in autism, but it leaves out the potential role of the very much neglected meninges in the development of autism. Theo agreed this was an intriguing notion and one of my projects is to finish a review of this factor with Theo in early 2014. What I now theorize happens in autism is somewhat like happens in experimental models of multiple sclerosis – although obviously different in timing and specificity.

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AND

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The meninges make the EAF which fills the subarachnoid space – that same EAF and subarachnoid space which is observed to be increased both both us, Bradstreet, et al., (2104), and Shen, et al., (2013).  In the research above, the inflammatory changes in the subarachnoid space, what both Shen, et al., 2013 and we think is is happening, induce changes in the microglial cells of the cortex making them more appear more inflammatory and less ramified (supportive).

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The cells are noted to be round and this is the way they look when they are inflammed.

In direct distinction, GcMAF treated microglial cells convert to the supportive ramified state. This means that the effect of GcMAF on microglial cells and macrophages is NOT inflammatory, but the opposite – anti-inflammatory.

In findings soon to be published, the images dramatic support this effect. I believe the shifting of macrophages and glial cells to anti-inflammatory states can explain why and how the mother’s story of her son’s recovery happened. To more fully understand this we need to understand the birectional role of TNF-alpha on memory and brain development.

TNF-alpha is one of the most potent pro-inflammatory mediators of the immune system.  At proper concentrations it is required for development of memory and synaptogenesis.  At pathological levels it destroys synaptic communication and is part of all neurodegnerative disease states including Alzheimer’s. New evidence points to the effects of TNF-alpha on NMDA receptor function.

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In my clinical practice, I use MgThreonate routinely and it is nearly always helpful in autism. The mechanisms are speculative but it is both effective at NMDA-R restoration as noted above as well as a direct anti-inflammatory.

Tying these seemingly unrelated observations together gets me to where I think autism is taking our understanding.

1). Epigenetic, both prenatal and postnatal effects influence the priming of microglial cells and most assuredly mast cells as well.

2). Mast cells and macrophages contribute to inflammatory changes in the meninges.

3). The immune changes in the meninges opens the tight junctions in the capillaries and allows extra fluid to accumulate in the subarachnoid space.

4). The increased EAF also carries within it the inflammatory chemistry of the mast cells and macrophages.

5). This message also influences the microglial cells and the mast cells resident in the brain.

6). This disrupts minicolumn function and structure.

7). This process prevents the creation of proper harmonic communication in the electrical properties of the brain.

8). The end result is autistic symptoms.

Presumably GcMAF and Magnesium threonate work to restore both microglial cells and macrophages to the ramified supportive non-inflammatory state.  The effect of mast cells in unknown.  But with all of this I believe 2014 is going to bring some amazing breakthroughs for relieving the suffering of autism.

So Happy New Year – 2014

Italian Inspirations for Therapies in Autism

A mother’s report of rapid reduction in aggression and self-injurious behaviors in her 8 year child with autism following GcMAF

The following is copied directly from and email I received and used with permission. I am proud to have been a part of uncovering this therapy for autism and you can read the full paper at the following link: http://www.la-press.com/initial-observations-of-elevated-alpha-n-acetylgalactosaminidase-activ-article-a3450

I do not recommend using this therapy without expert advise from a physician.

Dr. Bradstreet,

I just wanted to update you on D’s progress with GcMAF. We just took our 10th shot. It has been nothing short of amazing the transformation he has made. Our biggest gain by far has been a total elimination of aggression and SIB (self-injurious behaviors). Over the last 6.5 years we have tried almost everything to help D. We have done Yasko (4 years), IVIG, GFCF, SCD, 20-25 hours a week of ABA, ABA based school program, UCLA partial hospitalization program, LDN, Homeopathy, Risperdal, Zyprexa and much much more. Some things helped, but all in all just not that much.

My biggest fear was that one day I would no longer be able to control D, and that time was fast approaching. At over 75lbs and almost 5 feet tall sometimes it would take 2 or 3 people to control D when he went into a rage. Even when he was in a good mood, and no demands we put upon him he would attack people. Daily he would bite, scratch and head-butt. This often resulted in school staff being sent home with injuries,or sent to see a doctor.

By our 4th week on GcMAF we have seen a 75% reduction in aggression and now at our 10th week we have not seen any aggression in over a month. I want to thank you from the bottom of my heart for bringing GcMAF to the autism community it has changed my son’s life.

D still has many challenges, he’s nonverbal, has OCD and is not fully toilet trained. We still have a lot of work to do. But every week is better than the last and we are hopeful for D’s future.

Thank You,

Rosemary

Research on Nagalase and GcMAF now published in Autism Insights

I am happy to announce the publication of our initial observations regarding the important issues of Nagalase activity in ASD.  The lab test itself only cost $65 from Health Diagnostics/ELN.  Unfortunately it is generally not covered by most insurers in the US, but it is a worthwhile examination in my estimate.

This work represents the first clinical report of Nagalase activity in an autistic population. The article presents the first 40 children evaluated from 2 years ago. Since then and in collaboration with Dr Antonucci in Italy, we have observed over 1400 clinical cases. We will be collating our combined experiences and presenting-publishing a much larger series in the near future.  Simply stated, both Dr Antonucci and I believe Nagalase and GcMAF therapy represent  breakthroughs in autism-related comorbidities and therapies. We do caution parents enthusiastic to try this intervention to seek appropriate and experienced medical supervision. I am aware of numerous physicians in the US and around the World using this intervention. 

Please Note: Neither the lab test, nor GcMAF are approved for diagnosing or treating any condition despite a substantial body of research in peer-reviewed journals over the past 2 decades.

You can read and download the entire article from the Libertas Academia website through the following link. If the link doesn’t work in your browser just copy and paste it into your browser.

La Press

http://www.la-press.com/initial-observations-of-elevated-alpha-n-acetylgalactosaminidase-activ-article-a3450

Initial Observations of Elevated Alpha-N-Acetylgalactosaminidase Activity Associated with Autism and Observed Reductions from GC Protein—Macrophage Activating Factor Injections

Authors: James Jeffrey Bradstreet, Emar Vogelaar and Lynda Thyer

Publication Date: 10 Dec 2012

Citation: Autism Insights 2012:4 31-38

Abstract

Background: Autism spectrum disorders (ASD) are developmental disorders affecting 1:88 children, and which appear to be associated with a variety of complex immune dysregulations including autoimmunity. The enzyme, alpha-N-acetylgalactosaminidase (Nagalase) deglycosylates serum Gc protein (vitamin D3 – binding protein) rendering it incapable of activating macrophage defenses. Increased Nagalase activity has been associated with a variety of malignancies, immune disorders and viral infections. Macrophage activating factor (GcMAF) has been repeatedly published as an intervention to lower serum Nagalase activity for a variety of cancer and HIV patients. GcMAF is a naturally occurring protein with well-established safety and therapeutic benefit(s) supported by numerous human studies.

Methods: Initially, parents of 40 individuals with ASD sought testing for Nagalase serum activity as part of an evaluation of immune dysregulation. Nagalase enzyme activity measurement was performed by the European Laboratory of Nutrients (ELN), Bunnik, the Netherlands, using an end-point enzymatic assay of a chromogenic substrate. Some parents of patients with elevated Nagalase activity opted for weekly GcMAF injections provided by Immuno Biotech Ltd., Guernsey UK (www.gcmaf.eu). GcMAF is purified from human serum obtained from the American Red Cross using 25-hydroxyvitamin D3-Sepharose high affinity chromatography. The protein is then further diluted to obtain therapeutically appropriate levels for patients based on their clinical presentations.

Results: Individuals with ASD (32 males and 8 females, n = 40, ages: 1 year 4 months – 21 years 2 months) had initial and post treatment assessment of Nagalase activity. Dosing of GcMAF was recommended based on previously reported response curves adjusted by the treating clinician for age, weight, and Nagalase levels. The average pre-treatment Nagalase activity of the autism group was 1.93 nmol/min/mg of substrate. This was well above the laboratory reported normal range of <0.95 nmol/min/mg. For the ASD group the average level at the time of second testing was 1.03 nmol/min/mg, reflecting an average reduction of 0.90 nmol/min/mg (P < 0.0001). Apart from the likely immunological benefits of lowering the Nagalase activity of these individuals, uncontrolled observations of GcMAF therapy indicated substantial improvements in language, socialization and cognition. No significant side-effects were reported during the course of injections.

Conclusions: In this first report of Nagalase activity in patients with autism, it appears that most individuals have substantially higher levels than the expected healthy ranges. Although Nagalase is a nonspecific marker of immune dysregulation, its observed levels in autism may have both etiological and therapeutic significance. Importantly, this is also the first report of reduction of Nagalase activity in an autism population with GcMAF injections.

Aidan’s Story

I spoke to Aidan’s mother a few days ago and his story was remarkable.  More and more parents are telling me the same thing.  In this case Aidan’s mother has done an excellent job of detailing his response to immune therapy using the macrophage regulator – GcMAF.  This simple molecule has been established in the medical literature as a treatment for HIV and cancer, and appears to have potential in ASD as well.  So here is his journey.

Background/Synopsis: Aidan was first diagnosed with Severe Autism at 24 months of age. He was put on a strict dietary and supplement regiment immediately in conjunction with ABA Therapy, with marginal results—small, incremental improvements in his progress towards neuro-typical behavior. Aidan was first seen by Dr. Bradstreet August 2012, at 3 ¾ years old.  He was given GcMAF injections, once a week for 8 weeks (thus far) in addition to his already established supplementation. (Dr’s Note: GcMAF is adminstered by the family at home as a simple injection much like an insulin shot).

Since seeing Dr. Bradstreet and introducing GcMAF 8 weeks ago:

Verbal–Since the latest changes prior to initiating GcMAF, Aidan’s spontaneous verbal expression has almost tripled in only 8 weeks. From an average of 40 coherent verbal exchanges daily that were mostly prompted just prior to GcMAF (in conjunction with the aforementioned diet/supplements), Aidan now speaks approx 100 coherent verbal exchanges daily of which 80% are spontaneous.

Verbal communication cont—there is an increase in our son’s deliberate formation of words and sentences, with more clear expression of wants and needs.

Eye-Contact—has improved significantly–from moderate (50%) eye contact prior to GcMAF to deliberate and consistent eye contact (90%) with his parents, sibling, neuro-typical peers, and therapists. Aidan displays his displeasure of being ignored by family members, when we become preoccupied by distractions, by placing his hands on our cheeks to maneuver our faces to gaze into his eyes then making his request or comment. Even if it is simply “hi mommy”, he expects our undivided attention and eye contact is his new and appropriate way of ensuring that (versus undesirable behaviors that previously dominated our lives).

Social Interaction—within the past several weeks Aidan has sought out social interaction beyond his normal routine. Prior to GcMAF, Aidan would occasionally seek interaction, often preferring to be in his own world and playing independently 90% of the time. Now he consistently seeks interaction with all family members, has a stronger and genuine need for interaction with his sister, and seeks real interaction with peers. Aidan will seek out a family member to play with him 60-70% of the time.

School—he was not found amongst his special needs peers on the playground this week. Having wondered off to a segregated area where the neuro-typical children play, he was found by the teachers “blending in with the crowd” and playing appropriately with the “normal” children. The teachers even indicated they had a difficult time locating Aidan because his behavior resembled a neuro-typical child; therefore he did not stand out.

Temper-tantrums—there has been a significant decrease in temper-tantrums since 8 weeks ago. Former frequency and amplitude of aggressive outbursts has dropped to those expected of a neuro-typical 3-4 year old boy.

Heightened awareness, conceptual expression and interpolation—while Aidan demonstrated a degree of ability to interpolate and problem solve with abstract concepts, he is demonstrating and expressing stronger abstract comprehension to date since starting GcMAF 8 weeks ago. One Example: when pulling into the garage with his mother during the work day, he noticed his father’s car was already parked in the garage at the house. He became excited, and communicated to his mother that daddy was home, and that he wanted to see daddy.

Conclusion: We are elated with the improvements Aidan has made since beginning this treatment and feel that this intervention has had more influence of his progress than all other interventions cumulatively. We anticipate continued progression toward neuro-typical function as we eagerly move forward in Aidan’s GcMAF treatments.

Dramatic parental comments of recovery from autism

It is wonderful to be involved in the process of helping parents to restore the fullness of life to their children. Below is an email I received today and was asked by the parent to post on the blog.  It is wonderful and humbling all at the same time.

Hi Dr. Bradstreet,

I want to share our son’s progress, improvement and also want to express our hearty thanks to you in your Blog, but I am not able to post it.

So below is my son’s progress and improvement:; please post it on you blog, so that it will help to the parents who’s kids are having the same problem.

-Thanks,

Mom & Dad

***************************

My little boy was 3 years old , I realized that he has problem with socializing, tantrums.

He also has problems like constantly jumping, throwing up the food.

His speech didn’t make sense, he cannot pay attention, No eye-to-eye contact, he cannot have conversation (only one way talk), cannot play with other kids, he did not know proper language, he repeated the same words every day.

His grasping power was excellent. He could put his learning into action.

He was scared to sit on swings, we could not take him out a lot because he has behavioral issues, he do not understand personal space, he grabs toys from his friends, he steps on his friends, He get over excited when he see lots of kids at a time and he start s annoying them as he do not know how to play.

I and my husband were totally confused!!!

He turned 4 in December 2011. All the issues I mentioned above still persist. We moved from NJ to Georgia, our best friend referred Dr.Jeff Bradstreet .Our journey started. He was diagnosed with high functioning with ADHD. With Bradstreet consult we have been pursuing biomedical treatments for 4+ months now, including GFCF dite, Vitamin  D3, Prevegan, Nystatin,  Culturelle Probiotics, Krill oil supplementation, and mild chelation  with DMSA suppositories every 3X week. His nagalese count  was 1.01.

I wanted to write about the progress is making followed by treatment advice including GCMAF injections and the pervegan capsule. Until now we did 10 GCMAF injections.

At first visit Bradstreet mentioned that he will be recovered by the time he turns 5.

He will turn 5 this December. He is on the way to recovery within 4 months.

Dr.Jeff Bradstreet is giving my son back to this world. I can almost see it already within 4 months.  It seems to be the medicine I have been praying for.

Dr started treatment with dairy and gluten free food based on his allergy test results. This mitigated his hyperactive or exhibited autistic behavior. I started to buy organic produce and stopped feeding anything made with artificial food coloring. This made a significant difference in his behavior. After GcMaf and calcium EDTA  his progress catch up the speed. 

Here are some improvements with GcMaf and calcium EDTA…

He can actually be quite for some time if he is been told, He is using the proper language ( he is speaking in our Indian language also)

he learned how to play with toys and  he is interested in new play like:

Legos, Puzzles, writing his name, colouring, doing art project, playing Ipad games etc..

now we can go to the movies, eat in restaurants, go the shopping mall, now the span time is

at least 3 hours,  after that he gets tired.

He don’t like his GFCF diet…. but still he eats sometimes he says to me ” mommy this food is not good can you plz make something else for me”. It breaks my heart.

He reminds me that he has to take tablets. He wants to be with the kids and play with them, He want to try new foods now, in the beginning he was a picky eater.

He takes his GcMaf injections, with no tantrums. When we go to doctor’s office to take IV

He says” it’s just a pinch that’s ok mommy…”.

Now he knows how to play, but still he needs lots of improvement with socializing, expressive language, personal space etc.

Now his world is different he want to go for a car ride, play music, dance with his friends,

He loves to sing a songs, he likes to go Chuck E Cheese’s

I will keep posting further his improvements.

Once again Thank you to our my friend ‘R’  . I have to Thank Dr.Bradsteet and God. I will continue to have strong faith towards Saty’s progress in coming months. I look forward to see my son as normal child. Now I have trust in god and Dr.Bradstreet that they will heal my boy.

Thank you to Dr.Bradstreet from very bottom of my heart.

 Mom.

Stem Cell Therapies (after GcMAF) Showing Promise in Older Children with Autism

I have know this young man, now 15 years old for a long time (12 years in fact). He has progressed with the help of a restricted diet, chelation of mercury, a variety of supplements and medications have had their beneficial effects. then about 9 months ago we started our homeopathic GcMAF and it was a significant boost to his language and appropriateness. Then as you will see the family sought the help of stem cells through EmCell.  You can read the story below.  I will be teaching on stem cells and GcMAF at Autism One in Chicago at the end of March and also in the UK at Brunel University in September. This family has also been able to greatly reduced the use of medications to stimulate focus and attention after stem cell therapies.

Look for my article on stem cells in Autism Science Digest – on newsstands everywhere.

Dear Dr. B,

I just wanted to update you on our son’s progress 6 weeks post Stem Cells . He is 15 years of age as of May 5, 2012.

He is a great kid that is still moderately affected from Autism (although much better than he was even a year ago). Since Stem Cells he has been much more compliant and aware of life. He comments on things now that before he was not at all interested in. His sleep patterns are improving, as we now have to wake him up in the mornings for school! (REALLY BIG DEAL!! since he used to be awake at 5AM). His teachers at school have commented that he is happy and showing much more personality than ever before.

We even see an overall growth in his level of maturity that is really exciting!! He still has a long way to go but by the Grace of GOD we will continue to push through this journey called Autism.

Blessings,

A Grateful Mother

SPEECH….Finally!!!!! (for a child with Autism) or What Do Jellyfish Have to Offer Autism Therapy???

Below is a direct cut and paste from the thinking moms revolution blog. It was posted by the mother (thinking mother) of one of my patients.  She does a good job of explaining my new approach and after this is posted I will (hopefully later today) post on the working hypothesis I have developed for how this combined effect is acting inside the body. To learn more about Prevagen® you may visit www.prevagen.com.  I do not suggest using this without consultation with a trained clinician. There is a lot of useful info on the blog and some fiery banter as well. 

http://thinkingmomsrevolution.com/read-the-blog-here/

Posted on April 24, 2012

Today is an awesome day, and this week was an awesome week.  My sweet little four-year-old is finally emerging and I am incredulous watching it all.

Harry was initially evaluated at 11 months.  Being a twin and all, it’s hard not to notice a difference when at six months a typically developing child crashes and burns while his other half finds wings and soars.  We found ourselves in the evaluation room at Babies Can’t Wait with our almost one-year-old who, we were told, was at a 0-1 month level with speech.  Right, so into speech therapy we went.  Once a week, then a few times a week with oral motor worked in, then the super-intensive-every-day-bring-on-the-PROMPT-Therapy-combine-it-with-PT-and-OT-and-pull-it-out style as Apraxia was suspected at 19 months when he received his Autism diagnosis.  It was confirmed around three, but treated as such the whole time.  Could not blow bubbles, sip from a straw, pucker for a kiss, blow a cotton ball across a table…so, we knew.  We also knew he had the capacity for language because he would randomly say words, spontaneously, in context.  He would smile sweetly in his crib, I would kiss him and he would look at me and say “kiss”.  And say not another word for months.

After 2 ½ years of intensive and cutting edge biomed treatments with some of the finest doctors in the country coupled with every therapy we deemed useful, classical homeopathy and the beginning of CEASE we still had no progress in speech…although our mito markers- initially 4 of 5- were essentially in the normal range, oxidative stress was gone, chronic constipation, gone as well.

Not complaining about any of that but I obsess about speech.  I dream about speech.  I perseverate on speech.  I stim on speech.  I mean, I NEED to hear what this sweet child has to say…even if it’s “Get that f*cking nasty a** supplement-filled syringe away from me already woman, and squirt it in your own stupid mouth!  And stick a b-12 shot in your OWN damn butt for a change!”  OMG would I LOVE IT if he said that.  I really, really would.

At our September DAN! visit our doc said he still considered Harry pretty severe because of the lack of speech and the number of interventions that had not worked.  I started to argue that I KNEW he had the capacity for speech and that I just needed to find the right thing to open it up, when he reassured me he was by no means giving up, but was thinking we might need to try something even further outside the box then we’d gone before.  Oh yeah, that’s why I love our doc.  He suggested running a test to see if Harry’s nagalese was elevated. Um, what?  Short and simple: Nagalese levels are elevated when the body is not effective in recognizing or fighting viruses.  Cancer and AIDS patients have elevated nagalese, and, as it turned out three weeks and a blood test later, so did Harry.  Short and simple again: GcMAF is the chemical your body naturally produces to fight viruses.  GcMAF is used in Europe to treat Cancer, but I was a little nervous.  It’s a human product (though virtually a homeopathic dose) which carries, at least, theoretical risk.  So I sat on the results and continued CEASE clears for a few months until I couldn’t sit on the results any longer.  I hopped online and read Dr. Bradstreet’s blog about it and decided it was time to act.

We scheduled some time with Dr. Bradstreet (who will be talking at AutismOne in May)  He took a look at Harry’s recent labs and noted high neopterin on his last urinary porphyrins test, which is a secondary indicator that GcMAF might be helpful, and noted his chronically low Vitamin D levels…another indicator.  We decided to give it a shot, literally, of course, because you give shots of GcMAF weekly.  His office made up a series of four homeopathic injections for us to give once a week and shipped them overnight.

We gave the first one in his thigh and within ten minutes we had a rash (if you read my blog post about CEASE two weeks ago, you will notice a trend).  For ten days we had spectacular rashes, but we saw gains from the get-go.  Day 2 he stood in front of the mirror, smiled and said “Hi, Harry!”  Um, what??

He started to spell three letter words on his Ipad.  His receptive language began to explode.  He understood so much more than he had in the past, and he began to follow simple directions like “put your shoes on” from across the room.   The auditory processing delay that had decreased with CEASE disappeared completely and he responded just like any other child.  School took notice and the reports home were reports you dream of receiving.  So we kept going, meeting with Dr Bradstreet every month, reporting progress, and receiving four more injections.  And the gains kept coming.  The child who could in September do two signs…”more” and “milk” had now mastered thirty and was using them in combination.  He was parallel playing with peers.  He was sharing toys, and objecting—not walking away—when something was taken from him.  He learned how to swim and COULD BLOW BUBBLES!  He started puckering to give kisses…the first one to his twin who has never once treated him differently because he has Autism (although she has, at times, treated him like her life-size doll…but I digress).

We were told in the beginning of the treatment that if you see speech from this it usually comes between 12-16 weeks.  After 12 shots, Dr Bradstreet suggested adding in Prevagen which is, um, jellyfish goo and its sold OTC at Walgreens so at around 13 weeks, we did.  Prevagen binds to excess calcium and Harry’s calcium has always been extremely high.  I was interested.

So back to our amazing week.  On Monday, he started nodding yes.  It was a waist-up effort and stiffer than you can imagine, but it was Yes.  And he has been able to repeat that over and over this whole week.  Consistency—what we strive for but very rarely get.  He started shaking his head No…finally…and I think he kind of likes it.  I got a few head shakes when he eyeballed the syringe with the Prevagen in it…I have a feeling jellyfish goo tastes pretty nasty.

Last Wednesday I picked Harry up from school and he ran full speed, smiling and hugged me, as now has become our long-awaited norm.  We turned and I said ‘say bye bye to your teachers’ and expected his usual cheerful wave.  He paused and grimaced, then with tremendous effort said “BYE BYE” and of course I screamed so loudly that he is probably still trying to recover his hearing BECAUSE HE SAID IT ON DEMAND!!!!!  Not a random, spontaneous word, but he listened and was able to repeat something back to me for the very first time.  Thursday, he did it again. And he did it again on Friday too…twice actually because I got the courage to ask him to try it again at home.

We had our follow up with Dr. Bradstreet on Thursday and I basically professed my undying love for him (but I promise, Dr. Bradstreet, I am a fan, not a stalker).  He professionally confirmed he was seeing the same thing with other patients using the combination of GcMAF and Prevagen (and probably looked into restraining orders, lol).  He also confirmed Harry’s second nagalase test was in and it was no longer elevated, but that he would like to see it even lower.  He made some other supplement suggestions that he thought might push speech along too.

Today is Saturday and we gave shot number 17.  I know you will not read this till it posts on Tuesday but man, was it a good day.  He said bye bye a few more times.  Mama Mac suggested having him say it to everyone we encounter and um, yeah, sorry everyone at the mall who even looked in our direction today and thanks for being such good sports.  Harry and I were in the car when his sister dozed off and I slipped him a treat in the form of a Teletubbies DVD.  He loves those four…aliens? (What are they anyway?)  but his sister and brother have moved on.  I asked him “What is Dipsy wearing?” and he looked at me and said “HAT!” and then looked so proud of himself for answering the question out loud.  YES! A HAT!  YOU ARE RIGHT!!!  My gosh I have waited so long for this brief conversation—yes, I’m calling it that—and man, do I appreciate it.  The Teletubbies then said “Big Hug!” and started hugging each other.  Harry looked at me and grinned with arms outstretched saying “HUG!”  YES!  You got it.  One smothering, completely-over-zealous-and-maybe-bone-crushing hug from Mommy coming right up pal.

This is working for us.  I think back to everything we tried over the last 3 years that didn’t work and I am thankful I never once doubted that we would find something that would.  I think doubt is probably the most toxic thing for an Autism Mom, like a gateway drug to despair and depression.  Don’t allow it in there people, no matter how hard it is; it’s like GMO for the soul and it will slowly kill your resolve to fight to get your child back.  Know that the Thinking Moms are here with you and don’t doubt for one minute that you can make your child’s life better in some way.  You can, and we are here to help.

And, incidentally again, TMR does not endorse any type of treatment, nor can we predict if this will help you & yours.  Just sharing my experience with this :) .

The Power and Mystery of Persistence

Every so often observations about nature and our human biology come in a way that just requires we accept before we understand.  I wish I could more fully explain the following story sent to me by parents who insisted and persisted in the use of GcMAF past the point where the levels of nagalase (a viral produced enzyme which digests the Vitamin D transporter protein also known as GcMAF) activity normalized. Would they have seen the same results if they stopped weeks earlier?  There is no way to be certain but I continue to hear stories where GcMAF was restarted after having been stopped and new benefits are observed, so it is likely the results were the effect of continued GcMAF therapy.  The science remains to be worked out more fully, but the results are impressive. Here is their story in their words.

Dear Dr. Bradstreet,

Our boy is finally having the language breakthrough with GcMAF that we’ve been hoping for! After about 26 injections, he spiked a fever of nearly 105 F, which lasted for about 24 hours. The next day, he broke out with herpes sores all around his mouth, and pimples on his chin. A few days later, he had a very fine red pimply rash all over his back.

At the end of his first day back at school, he ran up to me and said, “Mom, guess what? I had a great day at school today. I was a good boy so I got to watch a movie, Puss-in-Boots, and I swinged on the swings with Mr. P, and I played a game on the iPad, and I drawed a picture with green.”

Wow!! This is from a kid who has never been conversational. He is mostly a functional scripter, i.e., he has memorized whole phrases or sentences that he uses appropriately to get his needs met. Usually, when I ask him what he did at school, he responds with “I played on the computer.” Before, he did not want to tell me about his day, and he didn’t have the ability to tell me about the various things he did.

We are so excited to see his conversational language emerging. His teacher has confirmed that she’s seeing this as well, and I think she’s as excited as we are. She also noted that he is more social, that he won’t stop kissing the girls, and the neurotypical boys on the playground are fighting over who gets to be his peer buddy for the day!

Yesterday, he came up to me and said, “I think you need to give me a shot.” I wonder if he knows that the injections are helping?

I was really undecided as to whether to continue the injections after 16 weeks when his Nagalase levels fell into the reference range. I am so glad we did! I will keep you updated with any more changes as we continue.

Thank you so much!

J & R (parents)

“Hi Daddy” – More Evidence Autism Is NOT a Static Encephalopathy and Can Be Significantly Helped at ANY Age.

We all may have different opinions about what causes the symptoms we label autism or autism spectrum disorder (ASD). The mainstream view of autism is that it is a “static” encephalopathy with its roots in the womb or in genetic causes.  Neither events from the pregnancy, nor even genetic issues are necessarily fixed or static events with no hope of recovery.

ASDs are complex and still incompletely if not poorly understood disorders.  The cellular mechanism responsible for the symptoms of autism are even more mysterious to us.  There is, however, growing hope of recovery at any age.

For years I have observed that even the most substantially effected children have moments where they are profoundly better – perhaps only for mere fleeting periods of time.  This alone implies there is some interference with neuro-processing which is not always present at the same level.  Therefore, it is conceivable that this interfering substance is amenable to biomedical therapy.  Here are further parental observations supporting this notion.

Daniel is now 17 years old and for the past several years his parents and I were frustrated with the relatively poor rate of progress – that is until they initiated GcMAF supplementation for him. 

Dr. Bradstreet,

Last week our son Daniel came home from school and looked directly at me and said “Hi Daddy, I had a good day at school today.”  I smiled and said that is great, but inside I was absolutely floored.  What a great thing to hear from him.  For years we would ask Daniel “how was school today” and his pat response was “it was good”, not a bit more.  This however, was an unsolicited statement and I can’t tell you how fantastic it made me feel.  When I told my wife she was equally excited.  We used to ask him what he did at school and after prompting he would say PE, but now he says we went to the park or we did stretching, little things but so different than before. For years Daniel would only speak in single words or rehearsed phrases, suddenly he is using a few more complete and complex sentences.  Just last week my wife asked Daniel to come here, he responded “just a minute mom, the movie is almost over” very exciting.

For a few weeks we had been getting very encouraging reports from school on Daniel’s progress, it corresponded to when we started him on injections of GcMAF.  His teachers reported that his socialization has improved with his classmates, he actually goofs around with them.  He engages in dialogue with his teachers and his work in general was improved since we started the injections.  We had intentionally only told his main teacher that we were giving him these injections and asked her not to tell the others so as to get an honest assessment from them.  Their responses were unanimous in saying that Daniel has made great strides.  The stories they relate of how he laughs and plays with his classmates is very encouraging for us.  Seeing gradual improvements at home sometimes get lost in the daily rituals, but getting these unbiased reports from his educators has been truly amazing.  Last year at school he had a few behavioral issues, but thus far he has been getting great reports from school and no problems have been reported.

Daniel has been fascinated with books about castles and knights, as well as geography and architecture.  Lately he has been asking us to explain more about what he is seeing and also showing us what interests him in his books.  Thank God for Half Price Book Stores :-)  There are many changes that I am sure we have over looked but the bottom line is our son is suddenly making some important strides forward that have us and his teachers excited for the future.

Among other things we have observed is Daniel’s willingness to try new foods, a problem in the past.  He is more willing to try vegetables now.  Before, if it didn’t pass the texture or smell test, not a chance!  He may not always finish them, but his willingness to try new things is a positive for us and corresponds to the GcMAF injections as well.   I took him to the driving range the other day and he attempted to hit golf balls with me for about 20 minutes or so without complaints.  He let me show him how to hold the club and swing it, and actually hit a few good shots, my hope is to try him on a golf course in the future. 

We are very proud and encouraged about Daniel’s progress and can only attribute it to the GcMAF injections he has been getting.  Thanks Dr. B!

Jim and Carol

I am formulating a revision of my original hypothesis on how GcMAF may work in ASD.  For that we will look more into calcium channels and a big clue from Nature.  More on this soon.

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