Dr. Bradstreet Lecturing 4 times at Autism One Conference in Chicago Illinois in May 2015

Follow the link below to register.

http://www.autismone.org/content/conference-membership-registration

Dr. Bradstreet’s Schedule for Autism One 2015

THURSDAY

3:00 pm – 5:00 pm

Louvre 3 CME – CM…, Confere… Advances in Understanding the Gut-Immune-Brain Link in Autism — CME program for medical professionals
James Jeffrey Bradstreet, MD
FRIDAY

8:00 am – 9:00 am

Avedon Bio – B…, Confere… How Close Are We To An Autism Cure? Part 1
James Jeffrey Bradstreet, MD
FRIDAY

5:15 pm – 6:30 pm

Cassatt Bio – B…, Confere… Understanding the Power of Magnetic Resonance Therapy — MRT(sm) — from the Parent’s Perspective.
James Jeffrey Bradstreet , MD
Kevin Murphy, MD
SATURDAY

8:00 am – 9:00 am

Cassatt Bio – B…, Confere… How Close Are We To An Autism Cure? Part 2
James Jeffrey Bradstreet, MD

Lecture Highlights:

James Jeffrey Bradstreet, MD, MD(H), FAAFP, FMAPS

Dr. Bradstreet received undergrad and medical degrees from University of South Florida. His residency training was at Wilford Hall USAF Medical Center, with training at Brooks School of Aerospace Medicine and Randolph AFB. He is an adjunct professor and faculty for Autism Collaboration & Education at Western U in CA and a visiting professor at Southwest College of Naturopathic Medicine. He is extensively published on biomedical issues of autism and was PI of two landmark studies: 1) involving a new methodology to view the brain with ultrasound, and 2) a double-blind study of the use of transcranial magnetic stimulation using a method known as MRT, for the treatment of autism — both registered with clinicaltrials.gov. Phase one of the ultrasound study was recently published in Frontiers in Human Neuroscience, and the MRT study completed in June of 2014. He is director of the Brain Treatment Center of Atlanta and is licensed in Georgia, Florida, California and Arizona.

Special Report: During Autism One, Dr. Bradstreet will introduce new observations related to transcranial laser (LLLT) applications for autism, and announce the new collaborative efforts to improve the specificity of medical marijuana therapy for autism related brain syndromes. [Note; Medical Marijuana is only legally available in specific states. The federal regulations on these state rules are in chaos].

Advances in Understanding the Gut-Immune-Brain Link in Autism — CME program for medical professionals

This course will explore the latest research on the microbiota regulation of the endocannabinoid and immune systems. The attendee will become familiar with the components of the endocannabinoid system (ECS) and understand what fatty acids act as natural ligands for the various receptors. They will understand the difference between type 1 and 2 receptors as well as the transient receptor potential vanilloid type 1 ion channel and the unique G-couple receptors and their function. The process whereby dietary fats and carbohydrates act upon by the microbiome to create changes in ECS regulation and the implications for the brain’s intrinsic immune system will be presented. The course describes the critical role of Vitamin D, its receptors and transporter proteins, and their interactions with the ECS. Finally, the novel fatty acid: palmitoylethanolamide (PEA) is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. Has no binding to CB1 or 2, but attaches to peroxisome proliferator-activated receptor alpha (PPAR-α) and cannabinoid-like G-coupled receptors GPR55 and GPR119. PEA is a powerful regulator of mast cells and in both human and animal studies has anti-inflammatory properties, which have implications for ASD immune and gastrointestinal dysfunction.

How Close Are We To An Autism Cure? Part 1

Dr. Bradstreet has been involved in autism related treatment and clinical research for nearly 2 decades. During that time, the theory of a genetic cause of autism has continued to decline, while the emergence of the “environment-gene” interaction theory of autism has gained in favor among scientists and parents. Clearly, autism is one of the most complex of all human disorders and challenges our understanding of the gut ecosystem, the immune pathways in the gut and the brain, and, ultimately, the regulation of brain physics. As complex as all that is, pathways for healing have emerged and more and more children are experiencing dramatic improvements – some to the extent that everyone would consider them “cured”. This course will present the foundations of healing and serves as the introduction to next presentation.

Understanding the Power of Magnetic Resonance Therapy — MRT(sm) — from the Parent’s Perspective.

Dr. Bradstreet will introduce the science of MRT(sm) and the ongoing research into brain physics and then introduce a panel of parents to further describe a balanced view of what may be expected from this unique form of intervention. In MRT treatment, BTC has augmented the well-established and safe technique of transcranial magnetic stimulation (TMS) through a proprietary algorithm to deliver a patient-specific treatment based on the results of a quantitative electroencephalogram (EEG) and electrocardiography (ECG). In one expert’s words, “What the Brain Treatment Center has done is revolutionary. Using evidence-based principles with TMS, they have created a delivery system that customizes treatment based on the patient’s own QEEG….” [Dr. Kevin T. Murphy]. Dr. Bradstreet will share the one year outcome observations for the study patients.

How Close Are We To An Autism Cure? Part 2

Although toxins from industry, agriculture, and more shape the environment for children with autism, the largest and most impacted environmental factor for autism remains the internal ecosystem living in the intestines. That environment is shaped by complex communities of microbes interacting with the diet and the immune defenses of the child. The combined effect of environmental poisons and microbial chemistry directly influence the immune system in critical ways, while also affecting gene expression. The consequence of this interaction is disruption of the vital regulatory mechanisms of the endocannabinoid system (ECS). The ECS has control over mood, cognition, and immune regulation, and its dysfunction is recognized as the root cause of epilepsy, inflammatory bowel disease, cardiovascular disease, type II diabetes, obesity, and neurodegenerative illnesses like Alzheimer’s. Our new research points to the role of Vitamin D deficiency and changes in its binding protein, the gut ecosystem and dysregulation of the ECS as the primary issues in the majority of autism symptoms. Ultimately, the ECS also regulates brain physics in a way that disconnects neuro-processing. All of these issues must be properly repaired for each child to obtain their optimal functioning.

David’s parents want to share his “amazing” response to transcranial magnetic stimulation using the unique MRT protocol.

David is 16 years old and lives in southern Georgia about 5 hours away from our center in the Atlanta area. His parents asked me to post this on my blog “as is” with no redactions or edits.  They want to share their names so other parents will be encouraged that older individuals with autism can respond to MRT. Their willingness to come forward and share their son’s story is a gift for everyone’s understanding of how the recovery process occurs. And we all thank Dr. Yi Jin and the team at NBRL in Newport California for their support and development of the MRT program here in Georgia. And you can learn more about MRT programs in ASD and other applications at https://vimeo.com/braintreatmentcenter/videos 

Dr. Jeff,

We just wanted to write you a quick note regarding some of the changes we’ve been seeing since our son (David) started with MRT therapy at the Brain Treatment Center in the Buford, GA office last fall. We hope our observations help you in your ongoing evaluation of this treatment modality.

In short, our results have been amazing. David had a baseline EEG in September 2014 and came back a week later for a four-day trial run of MRT, plus another EEG to measure results after the trial treatment. In the next few weeks my husband and I noticed subtle changes. Our son seemed calmer, more able to control his emotions and to ask more in-depth questions. Example: David has a good diet. After MRT, he asked to try new foods. Any parent would be thrilled with that. He also started reading the labels of food & alerted Mom if something was not completely GFCF.

Another first, he asked in detail about his food allergies. He became a conscious participant in his recovery—something he seemed to want as much as we did. When we received the post EEG results, we started to understand these changes. There had been significant, documented changes in David’s brain functions in the areas targeted.

Encouraged, we brought David back for a full week of treatment at the end of October 2014. He experienced some heightened sensitivity with hearing and smell for a few days after the treatment. Then he started becoming more independent than ever before. We saw this first in his schooling.

David attends school online now. At first we had to drag him from his room and force him to do the lessons, completing half the work ourselves. Within a week after October’s treatment, he started wanting to do the work alone. He liked doing it and took pride in being able to do it. He ordered us “to leave him alone” so that he could go to school on his own. He said he would call us if he needed help. We thought we were hallucinating.

“Let me do it” became the new norm for David. Again he started asking more questions and asking for advice. He frequently thought about things Mom and Dad said to him, then returned hours later with a “Thank you,” informing us our comments made sense. “You were right all along” is now something our son tells us from time to time. To hear that from any teenager is rare. But the real payoff is knowing that our son can listen, take in what we say, then show appreciation. He recently completed a lesson in school about parenting and asked us later if “we went through all that” while raising him. That’s awareness!

In mid-November, David revealed to us he had a “secret” that he needed to tell. He feared we would be upset with him. He’s a teen, so we braced ourselves for the worst. David confided he had filled out an online form and had been accepted as a Wikipedia editor. We were in complete disbelief and checked it out. The son that once could not write a sentence without a meltdown was now a Wikipedia editor. All David’s submissions have been approved and published (see an example attached). We asked David when he started this. He said it was the end of last September– two weeks after the trial MRT. His Dad is an English teacher and measured his writing to be on the college level, and David had no help from us. It’s like the MRT cleared a path for his intelligence to come out.

In January 2015 David returned for his third week of MRT. The changes we have seen since are equally remarkable. David now self-monitors his bedtime so he can get eight hours of sleep each night. He sets his own alarm and gets himself up in the morning. He’s on a swim team and is ready to go of the mornings before Mom can remind him it’s time to leave.

He no longer needs help with daily lessons at school, which he insists on completing lessons by himself. Overall, he is a more mature, calm, happy, thoughtful and independent teen. We cannot say things do not bother or upset him. He still has occasional emotional outbursts, but they are about things that would upset any normal teen. His ability to deal with setbacks and to control what bothers him is undeniably different from his pre-MRT self.

As a family we have traveled hours to see you for more than ten years for treatment (and we thank God for you). During the long drives, David usually stims/tunes out with electronics. But driving to our last visit, David asked to play a new game: He wanted to ask 20 questions about Mom’s life. For over two hours he asked and I answered questions while we chatted about my childhood. When we arrived at the BTC office, David thanked me for being honest about my life. On the way back David wanted to know more about his Dad’s life. When we arrived home, our son said: “I never knew all this about my parents.” Indeed, he had never been able to ask before.

Since last May, David has been in enrolled in Gemm Learning’s “Fast ForWord” program to increase his reading fluency and comprehension. He has made satisfactory progress and, like schoolwork, we’ve struggled to get him to focus on it. After MRT, Davey’s progress and desire have skyrocketed. His teachers at Gemm even commented on sudden change. It was great to have third-part confirmation of our own observations. The only thing we can attribute the boost in progress to is MRT therapy, as we have not done anything else different.

The cost, time and travel for MRT therapy are a serious commitment. It hasn’t been easy, but the results have been worth every penny, every mile, and every night in a motel room. In our eyes, David is proof that MRT is a treatment that can make a huge difference. For the first time we have hope that David will make a full enough recovery to live an independent life. We encourage every parent to give at least the trial a chance. Children will react differently to any treatment. We feel like we hit the jackpot on this one.

Thank you, Dr. Jeff. You continue to be our shinning light of encouragement and hope for our son. Bless you for never giving up and for giving our David a solid chance in life. Thank you for bringing MRT therapy within our reach on the East Coast. You will forever be our hero.

Kristi & David Taylor

Lighting a Path for Autism Recovery?

Light energy is critical to human health.  We need the spectrum of blue light in the morning to signal out intrinsic production of melatonin 12-14 hours later in the day. Blue light in the morning is absolutely critical to proper sleep in the evening.  And the importance of restoring sleep cannot be over-stated. The human brain requires proper rest for proper function.

Photo from http://braintreatmentcenter.asia/english/sleep/

Swiss Researchers recently discovered the chronic sleep issues of modern teenagers were do to looking at computer screens and their phones late at night and the simple use of blue filtering lenses prevented the sleep issues.

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I have been studying the use of low level laser therapy (LLLT) in neurological conditions and this safe therapy will be studied at our center in Buford, Georgia near Atlanta.

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From what we know about autism, LLLT has many potential restorative features that warrant our attention. The figure below is from Hamblin’s group at the Harvard-MIT LLLT research center.

http://spie.org/Images/Graphics/Newsroom/Imported-2011/003573/003573_10_fig1.jpg

Figure 1. Possible mechanisms of transcranial low-level laser therapy (LLLT) for traumatic brain injury (TBI). Mitochondrial signaling causes increased neuronal survival; lowered edema, inflammation and excitotoxicity; and increased angiogenesis, neurotrophins, and neural progenitor cells. ROS: Reactive oxygen species. NO: Nitric oxide. NGF: Nerve growth factor. BDNF: Brain-derived neurotrophic factor. NT-3: Neurotrophin-3. [Michael Hamblin, Ying-Ying Huang, Quihe Wu, Weijun Xuan, Takahiro Ando, Tao Xu, Sulbha Sharma and Gitika Kharkwal. One exposure to a near-IR laser four hours after a head trauma significantly improves neurological performance and reduces lesion size.5 May 2011, SPIE Newsroom. DOI: 10.1117/2.1201102.003573]

I have established a team of international experts in LLLT to assist the development of programs for autism and traumatic brain injuries. LLLT may also have applications for ME/CFS Fibromyalgia patients as well. I’ll have more on this in the near future. 

Thinking Mom’s Revolution eConference on Medical Marijuana

Any person connected to TV or the internet is aware the cannabis revolution is here.  But why?  The apparent reasons are relatively simple: chronic diseases are not the product of pharmaceutic deficiency – meaning taking drugs doesn’t fix the cause. The endocannabinoid system (ECS) was discovered through marijuana research decades ago, but it hasn’t been until recently that the ECS has been more fully appreciated.  This system links what you eat to how you feel and how you live – including you mood and your immune system. It also decides if you get heart disease, diabetes and Alzheimer’s.  New data from our research would indicate it also regulates the expression of autism in a child’s development.  On Thursday at 1 PM Eastern US time I will be presenting a 1 hour lecture on the TMR eConference on this vital subject.  Regardless of your feeling on “weed” the ECS cannot be ignored and it is much more important than merely the marijuana effects.

Visit the TMR site here: the click below in the side doesn’t work but this one does. https://attendee.gototraining.com/r/2125765357871997185

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See you then! But until then think about these…

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Sorting Out the Confusion Regarding Hyperbaric Applications to Various Neurological Disorders

Hyperbaric Oxygen often referred to HBOT is a well-established and accepted intervention for many disorders ranging from gangrene to non-healing skin wounds and pressure ulcers for the bedridden. However, its potential applications are much greater than then presently accepted and FDA approved indications.  Sadly, the FDA approval process is very expensive and few institutions could ever afford the process of applying and even if they did they would never recoup the cost of the research and legal expenses required to get the next indication approved for HBOT.  The technology (hyperbaric chambers capable of the pressures required) are widely available in hospitals and HBOT centers.  So anyone pushing the new indication through the FDA would be doing it for the benefit of all centers and that is an unlikely business model for success.  Even more concerning is that third party payers use the FDA approval stamp as their threshold for reimbursement, so nearly all of the possible applications of HBOT to neurological disorders goes uncovered by insurers. 

We will take a look at some of the data the FDA and insurers are blind to, but first a little about my background in hyperbaric medicine goes back to my days in the US Air Force where I was trained in Aerospace Medicine; including Hyperbarics.  I worked at McDonnell Douglas (now Boeing) and participated in research regarding F15 and F18 pilot stress and ways to improve pilot g-force tolerance.  And yes this really is me on the wing of an F18 at Naval Air Station Lemoore, California, where I received training from  Marine pilots.

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PLOS is a highly respected open-access scientific journal and this team headed by the Institute of Hyperbaric Medicine in Zefrin Israel, has put together some excellent data regarding the application of HBOT to late effects of neurological injuries (both stroke and post-traumatic head injuries).  Lets look at the delayed benefits for stroke first.

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These images indicate the area of the brain damaged by a stroke and the effect of HBOT at restoring blood flow to that region even very late after the stroke (images gathered in the study are from 6-36 months after a stroke).  But restoring blood wouldn’t mean very much if it didn’t also restore function.  Here is a quote from the abstract: “HBOT protocol: Two months of 40 sessions (5 days/week), 90 minutes each, 100% oxygen at 2 ATA. We found that the neurological functions and life quality of all patients in
both groups were significantly improved following the HBOT sessions while no improvement was found during the control period of the patients in the cross group. Results of SPECT imaging were well correlated with clinical improvement. Elevated brain activity was detected mostly in regions of live cells (as confirmed by CT) with low activity (based on SPECT) – regions of noticeable discrepancy between anatomy and physiology.”

So this is very strong data in favor of using this particular protocol for post stroke patients.  For years I have advocated 2.2 ATA (about equal to 40 feet of water pressure) but at mere room air.  One of the reasons I favor this protocol over the 100% O2 approach has to do with the blood vessel constriction that occurs with 100% O2.  That tightening of blood flow is EXACTLY what we want in acute head injuries but it has always seemed less desirable in late effects. The 2.2 room air approach has also seemed very helpful and we are seeing recovery after severe (nearly fatal) head injury in the Hyperbaric PHP Center in Buford, GA. (More information is available at their website (http://www.hyperbaricphp.com/) and I suggest contacting Bill at the center if you have more questions.

Here is another publication from the Israeli team:

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And here is the overall effect on cognition from their research.

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The real question is this: given the terrible effects of head injury and stroke on the quality of life and productivity of the individuals suffering with these conditions, why don’t insurers pay for this therapy and why doesn’t FDA take the initiative to include these treatments in their approved applications of HBOT?  When you figure that one out let me know, but my guess is it all comes down to money and more indications means more expense for the government and insurance companies.  So for now, if you need this treatment it unfortunately be at your own expense. From all we know, that expense surely seems well justified.

Parents, Teachers, Therapists, and Relatives Praise MRT Therapy for Autism Spectrum Disorders.

The following comments are from an unedited email that I received today.  I added his pre – post images but the rest is just mom-speak. “Thank you so much for introducing us to MRT. I am a private person, and I do not share things on Facebook or Twitter. However, I do want to share my experience here so that other parents will learn about MRT and gave it a try. At first I was skeptical. I watched the videos of MRT patients on Vimeo, and I thought this is too good to be true.  Well, I want to say that MRT is very good and very true.

I saw immediate improvements in my child even while we were still undergoing treatments. He had less tantrums, I was able to introduce new foods with greater ease, he began interacting with strangers, he followed instructions on the first or second request. Then in the weeks following treatments not only were his gains sustainable–they didn’t even plateau. Everyone from his school teachers, speech instructors, and our family noticed the improvements. At school, he is more focused and completes his lessons. His previous outbursts and problem behaviors are a thing of the past. At home, his sentence structure has expanded to complex 10-12 words sentences.

We are able to talk him through situations instead of having complete meltdowns. He is able to adjust to changes in routines better and is now playing with more age appropriate toys like Legos and action figures. Last week I heard him playing upstairs with his Ninja Turtles. He was acting out a complex attack scene with villains and dialogue. I had never seen him demonstrate such imaginative play before.”

HIS PRE MRT BRAIN IMAGE SHOWING FRONTAL DISCONNECT

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HIS POST MRT BRAIN IMAGE SHOWING FRONTAL CONNECTIVITY

(Especially in Language and Cognitive Centers)

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“This therapy has been such a game changer for us. I would love to do future therapy if Dr. Bradstreet recommends it. I think one day my husband and I will look back at our child’s life, and we will reference it as "pre" and "post" MRT.”

A Grateful Mom

Dr. Bradstreet’s Comments:  This is a powerful intervention and I agree that for many children it truly is a game changer. In most cases like this, we will wait a minimum of 3 months to allow the child to re-adapt to their home environment and therapies and follow those changes before we recommend further MRT sessions. Its likely this child will benefit even more from additional therapies, but it is wise to observe the trends over time.

What is MRT?  It is a process of using repetitive transcranial magnetic stimulation at very special frequencies to affect a change in how the brain communicates. 

You can learn more about it from an earlier discussion on this blog. 

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National Autism Association Conference Features Dr. Jeff Bradstreet

One of the more enjoyable places for a conference with excellent facilities and a great selection of speakers is the NAS Conference in Florida.  I strongly recommend it to everyone with an interest in Autism and I will be sharing new data on a variety of diagnostic and therapeutic approaches which promise to provide many children with renewed hope.  See you there!

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