Research on Nagalase and GcMAF now published in Autism Insights

I am happy to announce the publication of our initial observations regarding the important issues of Nagalase activity in ASD.  The lab test itself only cost $65 from Health Diagnostics/ELN.  Unfortunately it is generally not covered by most insurers in the US, but it is a worthwhile examination in my estimate.

This work represents the first clinical report of Nagalase activity in an autistic population. The article presents the first 40 children evaluated from 2 years ago. Since then and in collaboration with Dr Antonucci in Italy, we have observed over 1400 clinical cases. We will be collating our combined experiences and presenting-publishing a much larger series in the near future.  Simply stated, both Dr Antonucci and I believe Nagalase and GcMAF therapy represent  breakthroughs in autism-related comorbidities and therapies. We do caution parents enthusiastic to try this intervention to seek appropriate and experienced medical supervision. I am aware of numerous physicians in the US and around the World using this intervention. 

Please Note: Neither the lab test, nor GcMAF are approved for diagnosing or treating any condition despite a substantial body of research in peer-reviewed journals over the past 2 decades.

You can read and download the entire article from the Libertas Academia website through the following link. If the link doesn’t work in your browser just copy and paste it into your browser.

La Press

http://www.la-press.com/initial-observations-of-elevated-alpha-n-acetylgalactosaminidase-activ-article-a3450

Initial Observations of Elevated Alpha-N-Acetylgalactosaminidase Activity Associated with Autism and Observed Reductions from GC Protein—Macrophage Activating Factor Injections

Authors: James Jeffrey Bradstreet, Emar Vogelaar and Lynda Thyer

Publication Date: 10 Dec 2012

Citation: Autism Insights 2012:4 31-38

Abstract

Background: Autism spectrum disorders (ASD) are developmental disorders affecting 1:88 children, and which appear to be associated with a variety of complex immune dysregulations including autoimmunity. The enzyme, alpha-N-acetylgalactosaminidase (Nagalase) deglycosylates serum Gc protein (vitamin D3 – binding protein) rendering it incapable of activating macrophage defenses. Increased Nagalase activity has been associated with a variety of malignancies, immune disorders and viral infections. Macrophage activating factor (GcMAF) has been repeatedly published as an intervention to lower serum Nagalase activity for a variety of cancer and HIV patients. GcMAF is a naturally occurring protein with well-established safety and therapeutic benefit(s) supported by numerous human studies.

Methods: Initially, parents of 40 individuals with ASD sought testing for Nagalase serum activity as part of an evaluation of immune dysregulation. Nagalase enzyme activity measurement was performed by the European Laboratory of Nutrients (ELN), Bunnik, the Netherlands, using an end-point enzymatic assay of a chromogenic substrate. Some parents of patients with elevated Nagalase activity opted for weekly GcMAF injections provided by Immuno Biotech Ltd., Guernsey UK (www.gcmaf.eu). GcMAF is purified from human serum obtained from the American Red Cross using 25-hydroxyvitamin D3-Sepharose high affinity chromatography. The protein is then further diluted to obtain therapeutically appropriate levels for patients based on their clinical presentations.

Results: Individuals with ASD (32 males and 8 females, n = 40, ages: 1 year 4 months – 21 years 2 months) had initial and post treatment assessment of Nagalase activity. Dosing of GcMAF was recommended based on previously reported response curves adjusted by the treating clinician for age, weight, and Nagalase levels. The average pre-treatment Nagalase activity of the autism group was 1.93 nmol/min/mg of substrate. This was well above the laboratory reported normal range of <0.95 nmol/min/mg. For the ASD group the average level at the time of second testing was 1.03 nmol/min/mg, reflecting an average reduction of 0.90 nmol/min/mg (P < 0.0001). Apart from the likely immunological benefits of lowering the Nagalase activity of these individuals, uncontrolled observations of GcMAF therapy indicated substantial improvements in language, socialization and cognition. No significant side-effects were reported during the course of injections.

Conclusions: In this first report of Nagalase activity in patients with autism, it appears that most individuals have substantially higher levels than the expected healthy ranges. Although Nagalase is a nonspecific marker of immune dysregulation, its observed levels in autism may have both etiological and therapeutic significance. Importantly, this is also the first report of reduction of Nagalase activity in an autism population with GcMAF injections.

Autism Says Goodbye to 2013 and Hello to 2014: Breakthroughs and Progress

As it ended, 2013 turned out much better than I expected. I received a special present on Christmas Eve when, Itai Berger, Editor of Frontiers in Human Neuroscience, emailed me that my article on transcranial ultrasonography had been accepted and was available online in provisional format.  See abstract below.

Frontiers Abstract

This publication was the result of ongoing collaborations with my Italian colleagues at the University of Firenze (Florence). Professors Ruggiero and Pacini are pushing the immunological research in autism, chronic fatigue syndrome (ME/CFS), and cancer through their detailed laboratory investigations of the vitamin D binding protein – GcMAF. It was our shared interest in GcMAF that brought us together on the ultrasound research.  2012 ended with the publication of the first article describing Nagalase and GcMAF in ASD. (title below).

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One year later – to the day and after more than 10,000 article views – I was lecturing in Dubai at the 2nd International Conference on GcMAF Immunology.  The conference was well attended with physicians and researchers fro many countries. Pediatricians and Psychiatrists from Dubai, Jordan, Turkey, Italy, India and the US shared their experiences with GcMAF therapy in ASD.  It was very rewarding to hear their stories. They presented videos and collections of cases, all of which observed something similar to what i had already published: most children with autism respond vigorously to GcMAF and side-effects were minor and transient.

gcmaf conf dubai

I consult with families from 37 different countries around the globe and I hear the same stories about GcMAF regardless of the child’s ethnicity or culture. That likely speaks to the immunological ties between immune dysfunction and autism.  Below is one of the many extraordinary letters I received late in 2013.

Once upon a time my first born son was autistic.

       He stopped developing properly around the age of 1 and lost the few words and skills he previously had, though I don’t believe he was up to par even then. From there he slipped away from us into his own world and it was as if he couldn’t even see or hear us. He didn’t know he had a name, that we had names, or that we were even there. He didn’t babble, he didn’t play with toys, he didn’t even look up at people when they entered the room. When we had kids over to play he would hide in a corner and cry. He was chronically ill with one sickness after another, always tired, sleeping 14 hours at night and if we woke him up from his nap before 3 hours he would scream hysterically sometimes for 2 hours. The first doctor told me he was just a boy and boys develop slower, the second doc said we were just bad parents, and the third finally gave us a diagnosis at 27 months – 8 months after I had begun to worry.

     We tried everything; B-12 shots, ABA 20 hrs. a week, speech, OT, vitamin D, probiotics, and an extremely strict diet of no gluten, dairy, eggs, nuts, soy, fish, dyes, preservatives or anything artificial. These things did help a lot but even so it was an extremely difficult uphill battle of working months to gain a skill and if one person wasn’t consistent on the implantation of a goal he would regress immediately. There was a whole year that he woke up screaming every night for hours. Nothing I did helped and he couldn’t tell me what was wrong so I would resort to laying beside him and crying myself. He would wake up his baby brother who then also began screaming. It was a long year of screaming even from me! I once responded to one of his fits by having an all out screaming meltdown of my own, face down on the floor pounding the ground like a 2 year old. I was depressed, exhausted, and contemplated many times just ending it all…I have to be real because other parents need to know they are not alone in this. Besides the screaming he was always horribly constipated to the point of needing medical intervention, he had raging eczema head to toe, was allergic to literally everything; I knew my son was sick. I often told my husband, “some day 50 years from now the doctors will finally figure out that autism is a problem with the immune system but by then it will be too late for him.” I thought he would live with us his whole life and just continue to be a tired, sick, crying, itchy boy, who couldn’t get words out or look at us. Then my friend told me she found a doctor named Bradstreet who did believe it was immune related and was treating it! I had hope!          

     We started GCMAF and began seeing real progress after the level 7 dose. He seemed more energetic, cried less, and speech and eye contact were improving. Each week began to be amazingly better than the last and it felt like we were seeing actual recovery. Then after about a month he ended up in the hospital with a raging sinus infection of strep that led to an abscess behind his eye. This is a very rare complication but as I said, he had the immune system of a flea. He needed emergency surgery to save his eye but continued to battle the infection and a fever of 104 for 11 days until they resorted to surgery again, this time fully removing his right ethmoid sinus.  During his hospital stay and for 3 weeks after while he was still on antibiotics we couldn’t do GCMAF. His regression was significant. His speech went way back to about 9 months before we started GCMAF, he could only get a few words out at a time with great difficulty and even I couldn’t tell what he meant. He actually said to me finally, “mommy. help me,” and I said, “with what baby?” He struggled to get out the following, “with the…words…not come….out… good.” I cried because I knew he felt trapped in his own body unable to do what he was trying to. When I told him the shots were going to help him be able to speak he was eager to get them and reminded me every week on Wednesdays.

     When we started back up again and finally got the progress going he developed a rash which I now know was molluscum but at the time thought it could be related to GCMAF. We changed his dose from the level 12 once a week to level 5 twice a week and then we lost him. He went off into “autism-land” as I call it. Didn’t hear us, couldn’t focus, couldn’t even accomplish a single step direction and wandered around aimlessly. This dosage was working for other kids but not for him. We went back to level 12’s once a week and after 6 weeks of that he was in everyone’s mind effectively cured.

     His speech and OT discharged him, and after 2 weeks of being in a typical kindergarten class with no aid, the school coordinator told me he didn’t even need any special accommodations. We increased his school day to be full day now from 8:30-3:30 and even though he isn’t even 5 yet, there are zero problems. Zero. No fits, no meltdowns, no non-compliance. His teacher told me he listens in class, follows the schedule with no extra prompting, plays with kids on the playground, holds his pencil properly (big one!), and even sits with friends asking them where they live and what they ate for snack. After school he is able to tell me what he did, describe details about movies or books they read, sing me songs he learned, and he still has energy to play and doesn’t melt down when we get home. He never previously had the skills of recalling events or asking/answering questions properly until this. He currently has no therapy and we see no autism in him whatsoever. He says what he wants when he wants fluently, uses slang terms and laughs at jokes! He has even developed a little bratty back-sass attitude which my husband and I correct but then turn to each other and cry happy tears because it’s SO normal!! He was actually able to tell me that he likes the shots because his sleep is better, he has more energy, and he can speak better. He also hasn’t gotten sick once since the hospital stay back in March. His bowels are no longer dependent on laxatives daily as they were for 2 years. It’s like a dark cloud has been lifted and my son has been freed from his internal prison. We have the son we never had but knew was in there somewhere dying to get out. I have no doubt he will live a normal life and accomplish anything he wants to from now on. I don’t know if he will need GCMAF permanently or not but even if he does I don’t care. I will never let him go back into that cave. I firmly believe God answered my prayers and healed my son and he used Dr. Bradstreet and GCMAF to do it. Our son is healed and so is our family.

Forever indebted and grateful beyond measure,

His Mom

As a parent (and I am one with 2 boys, my own son and my step-son are both on the autism spectrum) these stories are powerful and touching.  But as a scientist I am driven to understand the mechanisms behind these types of anecdotes. The story relates a child rapidly changing state from significant and non-verbal autism, to observed to be normal by parents, teachers and therapist over a mere few weeks.  Autism has been felt to be a developmental and irreversible brain disorder. Clearly that is not always the case, as many stories of recovery are being published in the lay literature.

So how can this happen?  Mechanistically, I think this must represent the presence of an interfering inhibitor to normal neurological functioning. Whatever this substance or effect is, it acts very much like local anesthesia blocking signals in specific parts of the brain. In at least the example described above, that effect is then rapidly dissipated and the brain essentially wakes up. This story is common and doctors at the conference in Dubai presented their own versions describing very similar events in their practices as well. But not all children respond to GcMAF and that speaks to various subtypes of the disorder, some of which are readily recovered while others seem much more entrenched in whatever autism represents at the brain level.

It appears a significant subset of autism is immunological driven and that would fit the observations noted from around the world regarding GcMAF as a therapy. The graphic below is from a review article: Gesundheit B, Rosenzweig JP, Naor D, Lerer B, Zachor DA, Procházka V, Melamed M, Kristt DA, Steinberg A, Shulman C, Hwang P, Koren G, Walfisch A, Passweg JR, Snowden JA, Tamouza R, Leboyer M, Farge-Bancel D, Ashwood P. Immunological and autoimmune considerations of Autism Spectrum Disorders. J Autoimmun. 2013 Aug;44:1-7. doi: 10.1016/j.jaut.2013.05.005. Epub 2013 Jul 15.

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IN the graphic the authors depict the maternal immune system with its macrophages and other immune cells priming the response of microglial cells in the fetus.  Microglial cells are derived from macrophages which migrate into the brain during fetal development.  Those macrophages then undergo changes to become microglial cells.  They, however, maintain many of the features of their original macrophage immunochemistry. Missing from the diagram is another intersect circle representing the postnatal environmental effects. But regardless of that limitation in the representation, the hypothesis they propose is chronic immune – inflammatory changes in the brain secondary to microglial swelling.

GcMAF as noted in my paper, stands for Gc protein macrophage activating factor.  That name makes it sound like a pro-inflammatory molecule and as such based on the model above it would seem to be the last thing you would want to give to a child with autism.  As it turns out, the argument for chronic inflammation in the brain of children with autism is not universally agreed upon and other researchers, particularly Prof Manuel Casanova, have the opinion there is no inflammation in the autism brain.

I had the pleasure of sitting with Prof Casanova at several autism-related think tanks where the immune system was being discussed.  He took a decidedly differing view that there was no evidence of inflammation in the autism brain, but rather there was abnormal construction of the brain’s special electronics and at its smallest unit the minicolumn.  Casanova explained he had dissected scores of brains in great detail and inflammation was not present.  Instead the consistent finding was abnormal minicolumn construction. Below is an excerpt from a complex but insightful review we must consider.

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How is it that both camps: the inflammatory and the minicolumn, can be so divided in their views of autism?  First, I agree that autism is primarily influenced by epigenetic factors. In 2013 I participated in a review of these factors which is public access.

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In this review we wrote: “The term epigenetics was first coined in the 1940s by British embryologist and geneticist Conrad Waddington, who described it as: “the interactions of genes with their environment, which bring the phenotype into being” [17]. Our present knowledge enhances this earlier understanding, and epigenetics now evaluates the alteration of DNA transcription via variations in DNA methylation and histone modifications, but without alterations in the DNA sequence. These variants represent the epigenome, which in turn will be reflected in the transcriptome: that portion of the DNA which is being actively transcribed into RNA.”  The key is the environment regulates DNA transcription (messaging) without changing the sequence (no mutations) of the DNA.

Let’s return to the original article I posted on Transcranial Ultrasonography of the Brain.  An important part of that research was the publication of this research in Brain:image

And most importantly this observation; that there was too much fluid around the brain of children with autism.

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In the figure above I excerpted the images from Shen, et al., 2013 and added the arrows and notations of increased EAF.

In our paper on TUS we observed the same effect – increased fluid surrounding the brain. Below is a side-by-side comparison of fraternal twins from our paper in Frontiers in Human Neuroscience (2014).

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Under normal conditions the fluid (hydrostatic) pressure of the subarachnoid space (the fluid surrounding the brain) is not sufficient to keep the space fully open at the point where the brain folds itself closely to the skull.  In figure 13 from our paper, you can see the space of Twin A stays constant at 0.16 cm as the underlying brain compresses the arachnoid (meninges) of the brain, whereas with Twin B the space is compressed down to 0.01 cm. Now go back to the images from the Brain study of Shen, et al., 2013. If you study those images you will see that in the neurotypical child, the gyral summits (places where the brain folds up towards the overlying inside of the skull) come is very close proximity to the inner lining of the meninges and typically seem to be touching the membrane.  In our higher magnification views we see the same effect (Twin B). However, we and Shen, et al., 2013 observe the same increased distance of fluid volume in the case of autism.

So what does this mean?  At a recent MAPS conference I pulled Professor Theoharides aside to discuss my observations.  “Theo”, as well al call him, is a brilliant Mast Cell researcher and you can pull up his publications at his website: www.mastcellmaster.com.  I will insert a portion of one article, but realize Theo has extensively published on the immune and mast cell effects in ASD.

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The graphic below is in my opinion a more complete understanding of the immune and epigenetic effects than the one from Geshundheit, et al., 2013.

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This graphic gets us closer to what I think is really happening in autism, but it leaves out the potential role of the very much neglected meninges in the development of autism. Theo agreed this was an intriguing notion and one of my projects is to finish a review of this factor with Theo in early 2014. What I now theorize happens in autism is somewhat like happens in experimental models of multiple sclerosis – although obviously different in timing and specificity.

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AND

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The meninges make the EAF which fills the subarachnoid space – that same EAF and subarachnoid space which is observed to be increased both both us, Bradstreet, et al., (2104), and Shen, et al., (2013).  In the research above, the inflammatory changes in the subarachnoid space, what both Shen, et al., 2013 and we think is is happening, induce changes in the microglial cells of the cortex making them more appear more inflammatory and less ramified (supportive).

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The cells are noted to be round and this is the way they look when they are inflammed.

In direct distinction, GcMAF treated microglial cells convert to the supportive ramified state. This means that the effect of GcMAF on microglial cells and macrophages is NOT inflammatory, but the opposite – anti-inflammatory.

In findings soon to be published, the images dramatic support this effect. I believe the shifting of macrophages and glial cells to anti-inflammatory states can explain why and how the mother’s story of her son’s recovery happened. To more fully understand this we need to understand the birectional role of TNF-alpha on memory and brain development.

TNF-alpha is one of the most potent pro-inflammatory mediators of the immune system.  At proper concentrations it is required for development of memory and synaptogenesis.  At pathological levels it destroys synaptic communication and is part of all neurodegnerative disease states including Alzheimer’s. New evidence points to the effects of TNF-alpha on NMDA receptor function.

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In my clinical practice, I use MgThreonate routinely and it is nearly always helpful in autism. The mechanisms are speculative but it is both effective at NMDA-R restoration as noted above as well as a direct anti-inflammatory.

Tying these seemingly unrelated observations together gets me to where I think autism is taking our understanding.

1). Epigenetic, both prenatal and postnatal effects influence the priming of microglial cells and most assuredly mast cells as well.

2). Mast cells and macrophages contribute to inflammatory changes in the meninges.

3). The immune changes in the meninges opens the tight junctions in the capillaries and allows extra fluid to accumulate in the subarachnoid space.

4). The increased EAF also carries within it the inflammatory chemistry of the mast cells and macrophages.

5). This message also influences the microglial cells and the mast cells resident in the brain.

6). This disrupts minicolumn function and structure.

7). This process prevents the creation of proper harmonic communication in the electrical properties of the brain.

8). The end result is autistic symptoms.

Presumably GcMAF and Magnesium threonate work to restore both microglial cells and macrophages to the ramified supportive non-inflammatory state.  The effect of mast cells in unknown.  But with all of this I believe 2014 is going to bring some amazing breakthroughs for relieving the suffering of autism.

So Happy New Year – 2014

Contrasting Stem Cell Options in Autism

Picture: Neuronal (brain) Stem Cells

I’ve written a lot about our possible stem cell options on this blog, for Autism Science Digest and even chapters in scientific books, but nothing contrasts and compares our choices like the real world experiences of our children.

The young man I will present to you next is currently 12 years old. He had a prior history of autoantibodies to his blood vessels and had proven to be only slowly responsive to a wide variety of therapies when it came to spontaneous language.

In September of 2011 he had autologous (his own) stem cells harvested from his adipose and re-implanted in a clinic in the Dominican Republic.  This did seem to help his GI issues and calm his food allergies.  It did not result in changes in his language.

After his stem cell implant in the DR, I suggested we measure nagalase activity (viral protein marker) and it cam back elevated.  We started GcMAF to prepare his body for a second round of stem cells.  However, after his first course, his parents heard a lecture of mine on Fetal Stem Cells and the differences they presented over adipose (fat) derived stem cells.

They elected to pursue stem cells at EmCell in Ukraine. My logic was simply this; fetal stem cells create the growth factors and signals a child’s existing stem cells (living in his own brain) need to activate and then to potentially repair his brain.

The following email came from the child’s mother about 3 weeks after fetal stem cells were transplanted at the EmCell center in Kiev. After reading this, if you are interested in more information please contact my office and we can find time to discuss this further. 

FROM HIS MOTHER

hello everyone,

i contemplated on waiting for “more remarkable” improvements before posting my first update but a lot you have emailed and called….. so i thought to myself, these may be small improvements, but to other parents who have severely autistic children, these are major feats for them. some of you are on your way to EmCell treatments for your kiddos to so here you go!

1. He was able to tolerate sightseeing for hours and hours. after 2 days of Stem Cells (SC), we had time on the 3rd day to walk around kiev. matt walked a total of 3.5 km in a span for 5 hours. i couldn’t walk back another 3.5 km so we grabbed a cab back to our hotel. even at disneyland, we would have to get him a jogger stroller because he doesn’t tolerate walking for a long period of time.

2. in madrid, on our first night, our friend served jamon iberico (very thin sliced cured ham). obviously this is room temperature. for the first time ever, he didn’t request for microwave (his food has to be steaming hot and drinks have to ice cold) and ate a lot (and i mean a lot!) considering this is the first time he’s seen this. My son doesn’t eat food that he’s not familiar with, more so that it’s not hot. but he did!

we had 2 full days in madrid and would leave at 12:30pm, get to the restaurant for lunch 2:30-5:30, sightseeing for another 3 hours, dinner at restaurant 8:30-11:30 and get back to our friend’s place past midnight. the temperature here was 108 deg, matt is able to sit for 3 hours of lunch without his ipad (no wifi) and still walk for sightseeing under the heat! then sit for another 3 hours at the restaurant for dinner, by 10:30, he’d be all yawning but was game enough to sit until dinner is done by 11:30. he wasn’t tired or anything, i was tired because of the extreme heat and humidity. any child that will sit down for a 3 hour lunch or dinner would be bored to tears but not matt! except for a few whinings here and there but redirectable, he was really well behaved! and ate foods that he’s never had in america!

3. the whole week this week, he started cooking camp monday and went back to school on tuesday (which was his 12th birthday as well) morning and continued cooking camp in the afternoon. his whole demeanor has been happy in general. his academic performance at home with his lovaas therapist for 2 hours at home has been well, he is much, much faster in finishing up his math and comprehension worksheets without any whinings (okay, so his sched mon-fri 9-12 school, 1-4 cooking camp, 5:30-7:30 lovaas therapy at home) considering he’s had a whole day of activities.

4. yesterday morning in bed, dad was tickling him. he normally would say no tickle, i don’t want tickle. i was surprised when i heard him say “i don’t want TO BE tickled” the grammar and sentence structure was just perfect! i had to say what? and he repeated it, exactly the same. and then he said, “i want to blanket”. i corrected him by saying i want to USE blanket. he then points to the folded blanket above my head and says again, “i want TWO blanket” meaning he wants the 2nd blanket over the blanket he already has! he said it right and mom was wrong!

5. yesterday, he finished his stewed eggplant. a first! it kinda looked yucky to me….. but he finished everything! and he went to the park with his respite aid yesterday from 11-2 in the sweltering heat of 100 degress! his aid said he enjoyed playing on the swings, slides, he has never enjoyed going to the park. all he wants to do during weekends is go to the mall or cvs or target and go to the shampoo/lotion section to smell, smell, smell.

6. today, we had lunch at my uncle’s thai bbq restaurant. so all the food is already on the big table (buffet style) and everybody has started eating. he kinda looked like he was waiting for something, and he got his plate and sat by the table where all the food was in front of him. everybody was already eating and i guess since his favorite (and the only dish he would eat there) was still missing, my uncle jimmy (his grand uncle) asked him, what are you waiting for? he actually responds by saying “garlic short ribs”, i was surprised. coz he never responds to questions asked of him other than myself, yaya, dad or his therapists/teachers.

and normally too, once the garlic short ribs is served, he will NOT, ABSOLUTELY NOT, share with anyone else. if anyone gets a piece, he will get mad and start whining. well, today, i told him to get only 2 pieces and put the dish in the middle together with the rest of the dishes. he was fine. i told everyone to get, and people were asking maybe he’ll get mad and throw a fit. i asked him gently if it’s okay for other people to get, he said yes. and it was really fine! and he also ate another new dish.

7. lastly, we went malling today with my sister, we didn’t take him to bath and body works or victoria’s secret, he asked but we didn’t. and he was totally fine….. just so you guys understand, my son has a fixation with smelling. so a trip to the mall is not complete without going to those 2 stores. he was totally okay hanging out with us while we walked around for 3 hours.

so this is it for now. i really hope to share “miraculous” improvements soon. i know i have to patient, the EmCell doctors told us to wait 2-3 months to see the full effects of the stem cells, to give them time to grow.

i hope you all can continue to pray for his miraculous progress and hopefully on my next update, i will have “remarkable improvements” to share!

as always, i have to Thank God, for this opportunity for my son. and to put my trust in God that He will heal my boy, in His time, in His way, and according to His plan! I have to be faithful – AND LEAVE THE RESULTS WITH GOD.

P.S. i just have to add this, i was tucking him in bed just now, and he asks to watch cooking.  so i turn on the tv, etc, etc.  i put the blanket over him, and we have this conversation:

him:  i want massage please

mom:  where?

him:  head please (he puts his hands on his head)

mom:  okay (i put my hands on his head)

him:  healing, go back ukraine, healing.  doctors, healing.  autism be okay.  jesus heal autism

mom:  wow matt!  yes, you will be okay

him:  go back fabio hotel (our friend’s place in madrid, fabio is the son’s name, he thought we stayed in a hotel)

this whole exchange was spontaneous, no coaching, so out of the blue. 

all i can say is praise God!  more stories to share in Jesus’ name!

Adult with Autism Responds to Fetal Stem Cell Transplantation

One of the persistent myths about autism is that unless you fix the children by 5 years of age they just aren’t going to make progress.  Dan is here to tell you that just isn’t true. Dan is now 28 years old, and he first came to my practice in 2001, as a17 year old. Like many children of his generation of autism, he presented with chronic diarrhea and the loss of language after vaccinations.  In those days, there was a lot of mercury in vaccines.  And in a sickly child with chromic diarrhea – mercury – in any amount – is never tolerated. 

His family aggressively tried everything to recover him and with that they have been tireless. Dan has struggled with seizures, esophageal reflux and several bouts of regression. He remains extremely sensitive to anything happening with his gut. Early on we found both IgG and IgM antibodies to his brain blood vessels. His urine neopterin levels were significantly elevated, and this was consistent with a chronic viral infection.

Ultimately we also found antibodies to his folate receptors and elevated nagalase enzyme activity in his blood (another marker for likely viral persistence). GcMAF completely stopped his reflux and with that we saw some important gains, but Dan was still far from being independent or recovered from his many issues.

But that wasn’t the end of Dan’s struggles.  He was also found to have a very small deletion of the terminal end of chromosome 22 (perhaps the smallest deletion measured to date).  It is compatible with an unusual condition known as Phelan-McDermid Syndrome, but a much smaller deletion than typically seen with that disorder. 

This would never be the picture you might hope for when it comes to potential stem cell therapies. Yet his parents were undaunted and any chance was enough of a chance to get their attention and interest.

After several discussions, the parents (like I had for myself and my step-son) chose to try fetal stem cells at EmCell in Kiev, Ukraine.

So a picture is worth a 1000 words and countless blessings for Dan. 

Dan on the playground

This was the first time in 10 years Dan had been able to enjoy recreation and that is truly remarkable. His parents are seeing gains in many areas and we are all truly grateful to the expertise and experience the EmCell teams brings to the treatment of autism related problems.

If you want to know more about how to optimize the outcome of stem cell therapies, please contact me (470) 253-7445, my staff have been instructed to provide as many patients as possible with a donated 30 minutes of my time to discuss stem cells. 

A Real Life Changing Experience for a Child with Autism

I am in the process of preparing the data on the first several hundred children I have observed with GcMAF therapy for elevated nagalase activity.  The preliminary data is extraordinary. But not everyone who thinks they understand GcMAF therapy gets it. Many are using hugely too much and hurting children in the process. Please don’t overdose the children – if you are using the right GcMAF it takes very little to help. Our process involves homeopathic activation using classical techniques.  And when our techniques are used properly this is what we are hearing from the families so often.

Dear Dr. Bradstreet,

What has happened to my child? Could it be that it was only a few months ago that my little boy preferred sitting alone at the computer or lining up toy cars and planets in his room? It seems like it’s been a lifetime. Now, I look at my happy, interactive, responsive, 6 year-old child with amazement.

“J” began using GcMAF since 27 weeks ago and we noticed changes for the better almost out of the starting gate. Only 3 weeks in, my son asked to ride his bike. My husband and I looked at each other with dread. Unfortunately, in the recent past it took all three of us to make that bike go. My husband and I would use our hands to push his feet on the pedals while one of us attempted to steer. It was a backbreaking ordeal. Our son just couldn’t coordinate the mechanics of it. But, not this time…he jumped on that bike and rode all over the neighborhood. We couldn’t believe our eyes. Could it be the GcMAF? We just weren’t sure.

The IEP meeting was scheduled. We were just 4 weeks into the new school year and 4 weeks into using GcMAF. The teacher presented me with written work from the beginning of the year, then placed Jayden’s most recent work alongside it. Surely, it was from two different children. The earlier writing was erratic, with one letter written over top of the other, it was disproportionate, and trailed sloppily down the edge of the page. His recent work was neat, orderly, and consistently sized. It was even on the line. The teacher started gushing about his performance. He was starting to read and was learning full curriculum kindergarten academics. He was specifically excelling in math. Everyone around the conference table verbally gave each other a high-five for their achievement. “Now hold on,” I interrupted, “the success must primarily be attributed to the biomedical approach and the diet that we’ve implemented.” I gave them a brief explanation and we left the meeting feeling excited for what the future might hold.

It was not a steady climb up the staircase, however. We experienced some regression following dental surgery, but quickly got back on track (by resuming GcMAF).

Previously, I had a difficult time getting my son to respond when I called out his name. He would run out into the street without looking, if I didn’t stop him. He was able to parrot back canned answers to rehearsed questions. Now, here we are, 6 months later, and my son’s cognition has exploded. He laughs at jokes and is able to tell his own. He has started to ask and answer questions cognitively. He initiates and organizes the family during playtime activities. Recently, while in the pool, he touched his Dad’s hair and said, “Nice haircut, Dad.” At breakfast, after drinking his juice he asked, “Was that mango juice? I wanted pear juice.” The morning after I went to see a show he awoke and said, “Good morning Mommy. How was the show?” Just 2 months ago, a van from a local karate school brought children to the playground that we were at. My son was excited to play and ran over to a boy and gave him a two-handed chest shove. I apologized and quickly led him away before he got a karate chop. Just last week, we went back to that same playground. I watched nervously as “J” ran over to a group of three boys. I heard him say, “Come on guys, let’s play. Chase me!” And, you know what…they did! My boy led this group of “normal” boys all over that playground. One of the boys asked him what was his name. He told him, “My name is J***.” As I glanced around at the other parents scattered about the playground I wondered if I was the only one there who saw a miracle that day.

My son did experience some symptoms while using GcMAF. There was occasional regressive stimming, a rare fever up to 102, a few shooting head pains with sensitivity to light that lasted for only a few seconds, and he was often tired. But, those symptoms were easily lost in the shadows of the exceptional gains that we were experiencing.

The best part about GcMAF is that Jayden now frequently and spontaneously speaks those words, that for years, I’d longed to hear, “I love you, Mommy.” And, if that’s not a good enough reason to stick your kid with a needle 27 times, I don’t know what is.

Dr. Bradstreet, there are no words adequate enough to express my sincere and heartfelt appreciation for everything that you’ve done for “J”. Thank you for including us in your personal journey of discovery and healing. God bless you and your family.

Sincerely,

Dr. Bradstreet’s #1 Fan

SPEECH….Finally!!!!! (for a child with Autism) or What Do Jellyfish Have to Offer Autism Therapy???

Below is a direct cut and paste from the thinking moms revolution blog. It was posted by the mother (thinking mother) of one of my patients.  She does a good job of explaining my new approach and after this is posted I will (hopefully later today) post on the working hypothesis I have developed for how this combined effect is acting inside the body. To learn more about Prevagen® you may visit www.prevagen.com.  I do not suggest using this without consultation with a trained clinician. There is a lot of useful info on the blog and some fiery banter as well. 

http://thinkingmomsrevolution.com/read-the-blog-here/

Posted on April 24, 2012

Today is an awesome day, and this week was an awesome week.  My sweet little four-year-old is finally emerging and I am incredulous watching it all.

Harry was initially evaluated at 11 months.  Being a twin and all, it’s hard not to notice a difference when at six months a typically developing child crashes and burns while his other half finds wings and soars.  We found ourselves in the evaluation room at Babies Can’t Wait with our almost one-year-old who, we were told, was at a 0-1 month level with speech.  Right, so into speech therapy we went.  Once a week, then a few times a week with oral motor worked in, then the super-intensive-every-day-bring-on-the-PROMPT-Therapy-combine-it-with-PT-and-OT-and-pull-it-out style as Apraxia was suspected at 19 months when he received his Autism diagnosis.  It was confirmed around three, but treated as such the whole time.  Could not blow bubbles, sip from a straw, pucker for a kiss, blow a cotton ball across a table…so, we knew.  We also knew he had the capacity for language because he would randomly say words, spontaneously, in context.  He would smile sweetly in his crib, I would kiss him and he would look at me and say “kiss”.  And say not another word for months.

After 2 ½ years of intensive and cutting edge biomed treatments with some of the finest doctors in the country coupled with every therapy we deemed useful, classical homeopathy and the beginning of CEASE we still had no progress in speech…although our mito markers- initially 4 of 5- were essentially in the normal range, oxidative stress was gone, chronic constipation, gone as well.

Not complaining about any of that but I obsess about speech.  I dream about speech.  I perseverate on speech.  I stim on speech.  I mean, I NEED to hear what this sweet child has to say…even if it’s “Get that f*cking nasty a** supplement-filled syringe away from me already woman, and squirt it in your own stupid mouth!  And stick a b-12 shot in your OWN damn butt for a change!”  OMG would I LOVE IT if he said that.  I really, really would.

At our September DAN! visit our doc said he still considered Harry pretty severe because of the lack of speech and the number of interventions that had not worked.  I started to argue that I KNEW he had the capacity for speech and that I just needed to find the right thing to open it up, when he reassured me he was by no means giving up, but was thinking we might need to try something even further outside the box then we’d gone before.  Oh yeah, that’s why I love our doc.  He suggested running a test to see if Harry’s nagalese was elevated. Um, what?  Short and simple: Nagalese levels are elevated when the body is not effective in recognizing or fighting viruses.  Cancer and AIDS patients have elevated nagalese, and, as it turned out three weeks and a blood test later, so did Harry.  Short and simple again: GcMAF is the chemical your body naturally produces to fight viruses.  GcMAF is used in Europe to treat Cancer, but I was a little nervous.  It’s a human product (though virtually a homeopathic dose) which carries, at least, theoretical risk.  So I sat on the results and continued CEASE clears for a few months until I couldn’t sit on the results any longer.  I hopped online and read Dr. Bradstreet’s blog about it and decided it was time to act.

We scheduled some time with Dr. Bradstreet (who will be talking at AutismOne in May)  He took a look at Harry’s recent labs and noted high neopterin on his last urinary porphyrins test, which is a secondary indicator that GcMAF might be helpful, and noted his chronically low Vitamin D levels…another indicator.  We decided to give it a shot, literally, of course, because you give shots of GcMAF weekly.  His office made up a series of four homeopathic injections for us to give once a week and shipped them overnight.

We gave the first one in his thigh and within ten minutes we had a rash (if you read my blog post about CEASE two weeks ago, you will notice a trend).  For ten days we had spectacular rashes, but we saw gains from the get-go.  Day 2 he stood in front of the mirror, smiled and said “Hi, Harry!”  Um, what??

He started to spell three letter words on his Ipad.  His receptive language began to explode.  He understood so much more than he had in the past, and he began to follow simple directions like “put your shoes on” from across the room.   The auditory processing delay that had decreased with CEASE disappeared completely and he responded just like any other child.  School took notice and the reports home were reports you dream of receiving.  So we kept going, meeting with Dr Bradstreet every month, reporting progress, and receiving four more injections.  And the gains kept coming.  The child who could in September do two signs…”more” and “milk” had now mastered thirty and was using them in combination.  He was parallel playing with peers.  He was sharing toys, and objecting—not walking away—when something was taken from him.  He learned how to swim and COULD BLOW BUBBLES!  He started puckering to give kisses…the first one to his twin who has never once treated him differently because he has Autism (although she has, at times, treated him like her life-size doll…but I digress).

We were told in the beginning of the treatment that if you see speech from this it usually comes between 12-16 weeks.  After 12 shots, Dr Bradstreet suggested adding in Prevagen which is, um, jellyfish goo and its sold OTC at Walgreens so at around 13 weeks, we did.  Prevagen binds to excess calcium and Harry’s calcium has always been extremely high.  I was interested.

So back to our amazing week.  On Monday, he started nodding yes.  It was a waist-up effort and stiffer than you can imagine, but it was Yes.  And he has been able to repeat that over and over this whole week.  Consistency—what we strive for but very rarely get.  He started shaking his head No…finally…and I think he kind of likes it.  I got a few head shakes when he eyeballed the syringe with the Prevagen in it…I have a feeling jellyfish goo tastes pretty nasty.

Last Wednesday I picked Harry up from school and he ran full speed, smiling and hugged me, as now has become our long-awaited norm.  We turned and I said ‘say bye bye to your teachers’ and expected his usual cheerful wave.  He paused and grimaced, then with tremendous effort said “BYE BYE” and of course I screamed so loudly that he is probably still trying to recover his hearing BECAUSE HE SAID IT ON DEMAND!!!!!  Not a random, spontaneous word, but he listened and was able to repeat something back to me for the very first time.  Thursday, he did it again. And he did it again on Friday too…twice actually because I got the courage to ask him to try it again at home.

We had our follow up with Dr. Bradstreet on Thursday and I basically professed my undying love for him (but I promise, Dr. Bradstreet, I am a fan, not a stalker).  He professionally confirmed he was seeing the same thing with other patients using the combination of GcMAF and Prevagen (and probably looked into restraining orders, lol).  He also confirmed Harry’s second nagalase test was in and it was no longer elevated, but that he would like to see it even lower.  He made some other supplement suggestions that he thought might push speech along too.

Today is Saturday and we gave shot number 17.  I know you will not read this till it posts on Tuesday but man, was it a good day.  He said bye bye a few more times.  Mama Mac suggested having him say it to everyone we encounter and um, yeah, sorry everyone at the mall who even looked in our direction today and thanks for being such good sports.  Harry and I were in the car when his sister dozed off and I slipped him a treat in the form of a Teletubbies DVD.  He loves those four…aliens? (What are they anyway?)  but his sister and brother have moved on.  I asked him “What is Dipsy wearing?” and he looked at me and said “HAT!” and then looked so proud of himself for answering the question out loud.  YES! A HAT!  YOU ARE RIGHT!!!  My gosh I have waited so long for this brief conversation—yes, I’m calling it that—and man, do I appreciate it.  The Teletubbies then said “Big Hug!” and started hugging each other.  Harry looked at me and grinned with arms outstretched saying “HUG!”  YES!  You got it.  One smothering, completely-over-zealous-and-maybe-bone-crushing hug from Mommy coming right up pal.

This is working for us.  I think back to everything we tried over the last 3 years that didn’t work and I am thankful I never once doubted that we would find something that would.  I think doubt is probably the most toxic thing for an Autism Mom, like a gateway drug to despair and depression.  Don’t allow it in there people, no matter how hard it is; it’s like GMO for the soul and it will slowly kill your resolve to fight to get your child back.  Know that the Thinking Moms are here with you and don’t doubt for one minute that you can make your child’s life better in some way.  You can, and we are here to help.

And, incidentally again, TMR does not endorse any type of treatment, nor can we predict if this will help you & yours.  Just sharing my experience with this :) .

The Power and Mystery of Persistence

Every so often observations about nature and our human biology come in a way that just requires we accept before we understand.  I wish I could more fully explain the following story sent to me by parents who insisted and persisted in the use of GcMAF past the point where the levels of nagalase (a viral produced enzyme which digests the Vitamin D transporter protein also known as GcMAF) activity normalized. Would they have seen the same results if they stopped weeks earlier?  There is no way to be certain but I continue to hear stories where GcMAF was restarted after having been stopped and new benefits are observed, so it is likely the results were the effect of continued GcMAF therapy.  The science remains to be worked out more fully, but the results are impressive. Here is their story in their words.

Dear Dr. Bradstreet,

Our boy is finally having the language breakthrough with GcMAF that we’ve been hoping for! After about 26 injections, he spiked a fever of nearly 105 F, which lasted for about 24 hours. The next day, he broke out with herpes sores all around his mouth, and pimples on his chin. A few days later, he had a very fine red pimply rash all over his back.

At the end of his first day back at school, he ran up to me and said, “Mom, guess what? I had a great day at school today. I was a good boy so I got to watch a movie, Puss-in-Boots, and I swinged on the swings with Mr. P, and I played a game on the iPad, and I drawed a picture with green.”

Wow!! This is from a kid who has never been conversational. He is mostly a functional scripter, i.e., he has memorized whole phrases or sentences that he uses appropriately to get his needs met. Usually, when I ask him what he did at school, he responds with “I played on the computer.” Before, he did not want to tell me about his day, and he didn’t have the ability to tell me about the various things he did.

We are so excited to see his conversational language emerging. His teacher has confirmed that she’s seeing this as well, and I think she’s as excited as we are. She also noted that he is more social, that he won’t stop kissing the girls, and the neurotypical boys on the playground are fighting over who gets to be his peer buddy for the day!

Yesterday, he came up to me and said, “I think you need to give me a shot.” I wonder if he knows that the injections are helping?

I was really undecided as to whether to continue the injections after 16 weeks when his Nagalase levels fell into the reference range. I am so glad we did! I will keep you updated with any more changes as we continue.

Thank you so much!

J & R (parents)

GcMAF is exceeding my best expectations and parents agree

This next case is incredible and a true outlier in the spectrum of patients I have seen.  His original nagalase result was so high I was sure it was an error 7.8 (NL< 0.95).  These numbers were higher then any of my cancer patients, and nearly twice as high as my highest previously measured patient with autism.We’ve checked it 3 times and it was not an error. His numbers were even above a patient with acute lymphocytic leukemia and a woman with metastatic breast cancer.  I was naturally worried about the big “C” – the good news is there was no evidence of cancer in this child with autism (THANK GOD). And for thankfully good news; our most recent testing reveals a level of 3.60 – still very elevated, but more than 50% below our starting point.  I recommended this child start on very low levels of GcMAF (the vitamin D binding protein which is demonstrated to lower elevated nagalase enzyme levels).  So we still have a long way to go, but you can judge for yourself, based on this mother’s report, if this is a significant therapy for autism. After you read this post – like me and his grandparents – you should have tears of joy.

Hi Dr. Bradstreet,

I want to share a GcMAF update on my very challenged, slow-responder, older kid.  Mike turns 13 next month and has done intensive bio-med every day of his life since he was two.  He has progressed slowly over the years, and with a lot of hard work using the Rapid Prompt Method, he has learned to communicate by typing out his thoughts on a keyboard.  He has complete awareness and understanding of everything going on around him and can spell out  his amazing thoughts, feelings and knowledge, yet he presents as severely challenged and would be labeled as low-functioning.  His severe apraxia has been one of his biggest challenges.  At the beginning of this school year, he was able to imitate most single sounds, single syllables, and could repeat some words if you gave him a verbal model first.  He did have a few approximations for his words that he would say unprompted, however, it was often just the beginning sounds of the word.

Enter GcMAF.  Mike’s nagalase numbers were so incredibly high (7.8) that my hope was to just get these nasty viruses out of him and maybe on down the road we would see some good results with that.  However, after 12 weeks of injections, we are blown away by improvements in his articulation and in spontaneous speech!  I don’t think we have ever had spontaneous speech, other than requests for the common things he wanted or stim words.  I dropped off my older son at a class recently, and called out “See you later”, and was thrilled to hear Mike call out “Bye Lucas” from the backseat!  He has been answering simple questions/making comments in conversation that he would never have been able to do without hearing a word modeled, such as “What color do you want to paint with first?” (he answered “yellow”) and “Come see what I put on the board to practice handwriting” (his comment, “circle”).  He has also been pointing to objects, looking at you, and then saying the name.  Again, he could not do this unprompted before.  It’s not just that this spontaneous speech is very clear, what’s impressive is that it is there at all.

His articulation is improving so much that we are starting to record phrases and short sentences and send them to relatives.  My parents haven’t seen him since the week of his first injection and were in tears hearing his recording of “happy birthday grandpa”.  I am truly talking about a kid that did not have the ability to put syllables together for understandable speech unless you broke it down, and said it syllable by syllable with him.  I certainly don’t mean that all of the sudden everything is clear.  We recorded that phrase 3 times before I sent it to my dad.  But their comment to me (through the tears) was “nobody is saying it with him!”.  That’s what’s exciting!

Michael spelled out to me about a year ago “Mom, do you really think I have the ability to ever be able to speak?”  I said it then, and I’ll say it now… “We will never give up.  You never know what may come along”.  Mike’s confidence is soaring.  His speech is getting louder, which I’m sure is directly related to the confidence, and everyone around him is impressed with what they are seeing.  Last night Mike spelled out to me “Mom I’m talking.  I just feel better being able to talk a little”.

We also see notable changes in fine motor (tracing and mazes that are not hand-over-hand and some legible letters), body awareness (isolating limbs for exercises), and a huge interest in new foods (including onions, yuk!).

I am so thrilled with our progress so far.  We have tried a lot of treatments over the years, many helping in their own way, but we have never had one that has started to move his speech in the right direction.  Getting this as he approaches his 13th birthday… well…who would’ve thought?

Thanks for bringing GcMAF to the autism world!

Sincerely,

Mike’s Mom

Awesome – and this is why I became a doctor!

Further Observations from Parents about GcMAF and the Expanding Science of the the Vitamin D Receptor and Vitamin D Binding Protein.

So you think you understand Vitamin D and Vitamin D Binding Protein (AKA: GcMAF)? A great review of the non-classical effects of Vitamin D is posted here on the web by UCLA (http://ortho.ucla.edu/body.cfm?id=208). So, as noted in the diagrams below, stimulating the VDR has important effects on the immune system that are potentially what the autistic immune system needs.

 

image

 

 

 

image

Now the parental reality of what this complex chemistry means in the real world experience of a child with autism.

Dr. Bradstreet,

I wanted to share with you what a wonderful change has happened with our son since his treatment began with GcMAF. When we started the treatment his speech consisted of requesting specific foods and repeating some phrases upon our request. Other speech was rare. He did not ask or respond to questions. He did not tell us when he needed to go to the bathroom. Since GcMAF he will now answer yes and no questions. It is so cute to hear him say “No thank you.” And on Sunday evenings he will often ask “School on Monday?” The new words and phrases we hear every day are too many to list. He is still in a special needs classroom but he is now doing much of the same curriculum as the first grade students in the regular classrooms. He enjoys counting money and he has become interested in telling time. The school is thrilled with the progress he has made this year. We went from a 6 year old with an opinion about nothing to a six year old with an opinion about even which pair of shoes he wears to school. His expressive and receptive language continues to improve every day. If he hears us say the word ‘doctor’ he will shake his finger at us and say “I don’t want to go to the doctor yet. I don’t want an ouchy.” (He does not enjoy the nagalase blood draws) It is such a joy to see him so expressive!

When I have spoken to other parents about GcMAF I always tell them it was the best treatment we have tried and worth every penny.

Thank you so much!

CB

Rapid Response to GcMAF Noted by Mother of Child with Autism

Dr. Bradstreet:

I just wanted to send a quick email about “D’s” progress with the GcMAF injections. Even though “D’s” nagalase was only slightly elevated, I feel the injections have been extremely helpful.

“D” did experience a little more hyperactivity and aggravation when we started the injections, but this seemed to diminish after the 3rd & 4th injections.  (Interesting observation which I will discuss)

The most noticeable changes have come after the 1st and 2nd weekly injections when we began to hear improved and more advanced conversations from our child. “D” recently sat down with his father and initiated a conversation about puberty, testosterone, and emotions. At the end of their talk, “D” even shared an insight about himself: “Oh, I see. I’m letting my emotions control me sometimes, when really I need to be able to control my own emotions.”

After the 4th injection I experienced another sweet positive note. I was a little impatient about completing a clean-up task one day, and “D” put up his hand and told me, “Patience, my lady” and preceded to assist me with cleaning up!

This change has been with other adults too. D’s swim coach often pushes “D” with challenging 1500-yard workouts, swimming lengths of the pool without breathing, etc. Sometimes “D” will question his coach, complain, or become a little aggravated. Last Saturday at a local swim meet, his coach told me that there has not been one single complaint or argument from “D” in about a month—the same length of time we’ve been giving the injections.

Finally, while “D’s” facial eczema has been slight with an occasional flair-up during the past year, it has been pretty much non-existent after the 4th injection of GcMAF.

I’m looking forward to continuing the injections!

Thank you so much!

KT

So, subtle reactions of hyperactivity and irritability, but while he was also seeing very strong gains in cognition and language.

Again this rapid response seems to be too quick to be the result of viral abatement (my original hypothesis) and may be related to the functional activity of Vitamin D or the Vitamin D Receptor mediated DNA transcription (messaging) effects. Regardless I continue to be impressed with the frequency that I see these observations being expressed by parents, teachers, coaches and therapists.

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