The Autism Nexus: New Discovery of a Link Between the Gut Microbiome, the Immune System, Brain Dysfunction and Vitamin D and Vitamin D Binding Protein (GcMAF)

I am very proud of our recent work published in the highly regarded Journal of Inflammation.  By clicking on the hyperlink you browser should take you straight to the article which is available for no cost at the journal’s website. Once you are there click on the pdf button (the yellow arrow shows you where to click once you get to the article on the web).  Before you jump to article page let me explain in easier language why this article is so important. It is the first article any of us as authors have written that was accepted without any critique or changes, which means the reviewers thought very highly of it. While that is important, it is only part of the significance of our findings.  It has always bothered me that minor changes on the gut bacteria and yeast (microbiome) could result in wild and crazy changes in a child’s behaviors. While that observation is common among those of us treating the biology of autism, it was actually very difficult to understand mechanistically at the level of the child’s biology, at least until now.

We believe we have uncovered the nexus (intersection) of the observations regarding Vitamin D deficiency, GcMAF observed improvements in behavior, see: , immune dysregulation, brain inflammatory changes (mostly in microglial regulation), and the microbiome.  Briefly, the endocannabinoid system is part of the cell systems that regulate the immune system and the brain. In particular, it seems the CB2R (cannabinoid 2 receptor) reads the background environment of the individual (diet, microbiome, etc) and sets the tone of the immune defenses.  Last year we published the first observations of CB2 dysfunction in autism (J Autism Dev Disord. 2013 Nov;43(11):2686-95. doi: 10.1007/s10803-013-1824-9.). With this follow on work it seems likely that the endocannabinoid system is at the center of the complex biomedical disruptions underpinning the autism epidemic we are observing.  Now for your homework. Go the Journal of Neuroinflammation website and get the entire article. After you read it you can ask you questions. (use the link provided in the first paragraph).


JNI Article facepage

About Dr Bradstreet
Dr Bradstreet is a graduate of the University of South Florida College of Medicine and received his residency training at Wilford Hall USAF Medical Center. He is a Fellow of the American Academy of Family Physicians. He is an Adjunct Professor at the Southwest College of Naturopathic Medicine in Arizona. He is extensively published in the peer-reviewed literature on subjects of autism, oxidative stress, mitochondrial disorders, virology, hyperbaric oxygen, and toxicology (especially heavy metal chelation). He is trained in the the isolation and use of stem cells.

5 Responses to The Autism Nexus: New Discovery of a Link Between the Gut Microbiome, the Immune System, Brain Dysfunction and Vitamin D and Vitamin D Binding Protein (GcMAF)

  1. Bill Schindler says:

    Dr.J.F. you should be very proud I don’t know how you do it neither does Emily one man making so many differences in the world in so many ways God bless you always!!!!!!!!!

    Sent from my iPhone


    • Julie Jaeger says:

      I did my best to read this in my limited understanding of medical jargon so please pardon my questions if they are laughably off base….
      1) If there may be a connection to maternal vitamin D deficiency during pregnancy to increased risk of autism in the baby, do you think that has anything to do with the 2 facts that Arizonans have the highest reported cases of vitamin D deficiency(from hiding from this godforsaken sun) and we also seem to have one of the highest populations of autistic kids?
      2) Am I to understand that the “EC system gene” that is discussed is an identified genetic problem resulting in autism, particularly the cases that seem especially immune-deficient?
      3) Is the EC gene thing something that could explain why some kids have autism “triggered” by a vaccine? I have always thought my kids may have some underlying genetic mishap just lying in wait to be angered like Godzilla.
      4)Did anything in this study further our understanding of how long patients need to be on GcMAF to maintain results or if infact some may need it indefinitely because it is doing the job of the messed up EC gene?
      5) Did any of my questions even make sense at all or are you just laughing right now?
      6) Can you please put the key points of the study’s findings into really really simple-minded people english?
      Thank you, we are forever endebted to you! Continue your amazing work!

  2. Ellen Elley says:

    Thank you for this article. All I have to do is look at my daughter and know this protocol is working!

  3. Devon Collins says:

    Based on this article, wouldn’t one want to use GcMAF and CBD oil together?

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