Solutions for the Dysfunctional Interplay of Immunology and Neurophysics in Autistic Syndromes
April 23, 2013 6 Comments
I am pleased to announce my association with The Brain Treatment Center (BTC) in Newport California. Dr. Jin and his associated staff and researchers have made incredible breakthroughs in complex areas of brain functional restoration.
In 1998, Carol Stock Kranowitz wrote a book called the Out of Sync Child. It detailed her observations of sensory processing disorders in children she had taught over the prior 20 years. Although I am sure she didn’t intend the book to describe asynchronous neurophysics – her observations were true and ultimately insightful.
It turns out the brain cannot perform its many complex tasks without a high degree of synchronous electrical activity. Very much like computer circuitry – asynchronous brain activity uses too much energy to be efficient. That means those areas of the brain demand more oxygen and glucose, which results in excessive production of oxidative stress and mitochondrial overload. It also means they don’t share data effectively with other brain centers.
When it comes to autism, most of the observations from the BTC reveal 50% or more the brain in autism functions asynchronously, and we label those issues as autism.
The good news is a technique has been developed to restore synchronous activity and with that many children are seeing remarkable and rapid gains in language and cognition.
Figure 1. Major areas of the left hemisphere of the brain. Wernicke’s area is where words start to form and Borca’s area is where they are finalized prior to the message being sent to the motor cortex with the command to speak. The temporal lobe adjacent to Wernicke’s area is where the primary auditory cortex resides.
Figure 2. fMRI of the synchronous activity of the brain required to speak novel words.
Many areas of the brain connect simultaneously to create spoken language and it is easy to see how minor aberrations in these areas could result in difficulty with expressive language typically observed in autism.
Figure 3. This represents a color translation of the mathematical transformation of the EEG into a power-frequency map; meaning how much energy is present at different wavelengths. As you can see only about half the brain picks up this synchronized waveform. In the color map the left side of the brain shows the language and auditory cortex is not in sync and also includes the frontal cortex including the primary social cortex of the R frontal lobe area.
Figure 4. This imaging shows the out of sync areas of the brain are consuming the highest amount of oxygen, yet they are not effectively functioning.
Figure 5, Represents the same child’s brain after 3 treatments with magnetic resonance therapy – a special form of rTMS (external magnetic therapy). The color map shows very substantial changes in synchronized brain activity and with that language and eye contact showed very impressive changes.
This is a dramatic change in the sync pattern and with it a remarkable change in language, eye contact and reduced self-stimulatory behaviors. This child had been treated with GcMAF and with that it appears the brain was primed to rapidly respond. Its not that all children need some form of immunotherapy to respond to MRT, but in this case the response was particularly dramatic.
So how did the asynchronization of the brain happen in the first place? the evidence points to a immunologically mediated alarm signaled through the connections of the perivascular macrophage>endothelial (blood vessel) cells>astrocyte and microglial cells. These cells create the immune axis of the brain and it designed to nurture and protect the neurons (brain cells). If it triggers an alarm brain cells stop talking and so do kids with autism.
Figure 6. Represents this complex dynamic, but it does depict the extremely important interneurons that regulate the harmonic synchronization of the brain.
Figure 7. Here we see the intensely important relationship of the large electrical circuit cell (pyramidal) to the double bouquet interneuron cells.
The DB interneurons create the GABA that inhibits noisy signals and regulates the pyramidal cell’s activity. Those same DB cells also create reelin which build networks and connections for the brain. DB interneurons are very sensitive to immune alarm signals and appear to be a primary source of the immune axis disruption of normal brain harmonic signals.
It appears to me that with correction of the immune signals to the DB interneurons and then using MRT to capture the DB sync, child can be rapidly restored to higher function.
I will write more about this exciting breakthrough in coming weeks but for now I hope this starts you thinking and hoping.