Further Observations on GcMAF in Autism

My comments will follow this feedback on GcMAF for elevated nagalase from a mom.

Hi Dr Jeff,

6 days after first (GcMAF) injection I noticed the beginning of more intellectual observations and mature questions from him like: “What is hair made of?”… I say “cells”, he says, “What are cells?”… I say they are made of DNA from mom and dad, he says, “does that mean I have the same DNA as you and Rachel? (his sister)” …I say “yes”, he says, “so where did I come from before I was in your belly?” That’s where I choked and called my husband in to figure out what to say and also because I was so excited by all these great questions! :-)
This has been consistent throughout and after the 3rd injection which was last Saturday.

He does however appear to be having some more receptive language issues/auditory processing issues which cropped up recently which interestingly always seem to crop up when he is on an antiviral like valtrex (why we had to abandon that in the pas t— note: not prescribed by Dr Bradstreet). This appeared to coincide with the 3rd injection which was a little stronger.

He also has a mild epileptiform encephalopathy like LKS variant but hasn’t gotten IVIG in about 2 months. If this regulated calcium channels then potentially shouldn’t it IMPROVE subclinical seizure activity if it blocks calcium channels? Do you know if it regulates calcium channels to reduce hyperexcitability?

His originial nagalase was 1.9 about 3.5 weeks after ivig – I had heard ivig could possibly bind nagalase thus increasing blood levels so I’d be curious if kids on ivig have higher nagalase levels…

All in all though we’re pleased with his progress and I have heard it usually takes 4-5 weeks to even start seeing gains so we’re ahead of the curve!


This email I received is posted here with permission from the mother.  I t brings up some interesting points and some things that need to be responded to. 

1) There is no evidence or even reason to suspect IVIG alters nagalase transport or activity.

2) I have no evidence nagalase or GcMAF block calcium channels.  Presumably and I cannot find much at all in the literature about this – GcMAF which acts as the blood transporter of Vitamin D plays a role in calcium channel function through the VDR-nuclear effects of Vitamin D.  I do think some on my cases need less vitamin D and calcium on GcMAF but this observation is inconsistent. Abnormal regulation of calcium channels has been described in many disorder including certain types of epilepsy (absence) and chronic pain.  Exactly how GcMAF and Vitamin D or VDR effect this remains unclear.

3 Early response to low dose GcMAF is very intriguing and it is hard to imagine it is due to viral elimination – more than likely it is related to other factors regulated through the Gc – Vitamin D – VDR – Vitamin D nuclear effects (DNA transcription) that regulate this type of response.

It remains a remarkable observation that minute doses of GcMAF have such a dramatic effect on children with ASD.

About Dr Bradstreet
Dr Bradstreet is a graduate of the University of South Florida College of Medicine and received his residency training at Wilford Hall USAF Medical Center. He is a Fellow of the American Academy of Family Physicians. He is an Adjunct Professor at the Southwest College of Naturopathic Medicine in Arizona. He is extensively published in the peer-reviewed literature on subjects of autism, oxidative stress, mitochondrial disorders, virology, hyperbaric oxygen, and toxicology (especially heavy metal chelation). He is trained in the the isolation and use of stem cells.

16 Responses to Further Observations on GcMAF in Autism

  1. Rimma Brandin says:

    I just had result from my son’s blood test: nagalase is 1.3 normal range untill 0.95.
    Dr.Weaver in Columbia SC ordered for me after I asked him.
    Do you think my almost 18 years old with severe autism will benefit with GcMAF shots since it is
    only a little elevated.
    My financial situation does not allow me to do expensive treatment, he is on many supplements for a long time.
    Please respond if he could benefit from shots.
    Rimma Brandin

  2. Karin says:

    Dr. Bradstreet,

    Could some of the short-term improvements seen with GcMAF be explained in part by a decrease in TNF-alpha?

    I posted this comment several days ago on another of your GcMAF posts, but since I don’t see it showing up, I thought I would try reposting here:

    GcMAF ‘stimulates cAMP formation in human mononuclear cells’ (1), and also ‘Elevation of intracellular cAMP potently suppresses macrophage TNF-alpha production and modulates T-cell response by inhibiting TNF-alpha and IFN-gamma’ (2). I also see that ‘stimuli known to enhance cAMP are capable of selectively suppressing the activation of NF-kappa B’ (3).

    (1): http://www.ncbi.nlm.nih.gov/pubmed/21170647
    (2): http://www.ncbi.nlm.nih.gov/pubmed/14680506
    (3): http://www.ncbi.nlm.nih.gov/pubmed/15580656

    I don’t know how relevant this is but thought I would mention it. Could GcMAF directly decrease TNF-alpha?

    I wonder how autistic symptoms would respond to substances increasing cAMP levels like Forskolin supplements…

    • Under normal circumstances TNF alpha stimulates MAF so when we give it exogenously we bypass this pathway. I am not clear what the effect of GcMAF is on TNF alpha but I do not think it reduces it. I will look at this further as it is an interesting question.

  3. Giovanna says:

    I would like to know what is the low dose with which this kid started and how much the dose is being increased every week.
    Italian mom

  4. XGirl says:

    You need to be aware that GcMAF might open calcium channels!
    Do not supplement any calcium during or right after GcMaf treatment.

    Gcmaf increases the calcium in the cells (intracellular calcium) if the dose is too high. Calcium channels will be opened and there will be leakage of positive calcium ions and many strange symptoms, cramps, spasms, headaches, insomnia, and more. For this reason some of ME-patiens on GcMaf treatment needed to include intravenous magnesium for 4 weeks (2 per week) and this helped a little. ME-specialist Kenny DeMeirleir thought it surely must be 3 months with IV to stop the leak (the addition of extracellular Mg) although Nifedipine help to close calcium channels much faster. Blood analysis from the ME-patients confirmed too much calcium in the cell and low potassium and magnesium, although it does not give a complete picture. We talk about the cells in tissues and organs, etc., and not in the blood cell, although this gives an indication…

    Besides Gcmaf can create a lot of inflammation in the body (and high C4a) and it will take time to change it. Over activated macrophages are also associated with too much calcium in the cell, as too much calcium in the cell activates certain hormones – including some that produce acid in the stomach (inflammation of the stomach / intestine). C4a rised in the most blood samples from ME-patients on Gcmaf, This means that the gut is more leaky…

    • This is an interesting comment, but I am not sure I agree with the substance of it. GcMAF is also the vitamin D binding protein which is both cell membrane bound and free floating in plasma. It cannot open calcium channels by itself. It facilitates Vitamin D binding to the VDR and its transport. It is likely if you are experiencing issue with ME/CFIDS that it is not due to calcium channels but to the overall immune activation. I generally reduce both Vitamin D supplementation and calcium intake during GcMAF therapy as it seems they need less while on GcMAF.

  5. Hi Dr . Bradstreet , I have just started my 12 year old Autistic son on GcMAF . His Nagalase level was 1.00 . He is currently taking 175 Mg of Topomax for headaches . Is this drug contraindicated when using GcMAF ? Thank you for all that you do for our children .

    • To the best of my knowledge there are no medications that are absolute contraindications for GcMAF. On the http://www.gcmaf.eu website they list some relative concerns and some medications that would block the therapeutic benefit (mostly immune suppressive agents). I have not observed any issue with topomax and GcMAF, but you should consult your primary doctor on this issue.

  6. Nicole says:

    Would you suggest trying GcMAF prior to trying stem cells? My son’s nagalese was 1.0.

  7. Marcie says:

    Dr. Bradstreet,
    We are currently patients of yours and have a quick question. We were thinking of either starting HBOT or Gcmaf this summer. Our son struggles with expressive language and still Stims alot (humming). In most of his testing there is no issues other then oxidative stress. Which treatment would you feel that more results could be expected from in our case. Thanks Marcie

  8. Rolando Marriott says:

    Dr. Bradstreet,

    This observation/question is from a parent with a 4 year old autistic boy being treated by one your colleagues. He is making progress since we started treatment 7 months ago. Just as you are on your journey to help as many families as possible, I continue to research/educate myself on this epidemic to help our son recover. From researching, there was a Biological Medicine 2012 event in New York City. I could not make it but I saw your name as one of the attendees and a Dr. Magda Havas (http://www.magdahavas.com) . I recently have come across to the topic of “Health Effects of RF/Microwave Radiation/Dirty Electric”. A couple of Doctors have noted that it would be beneficial to create an EMF clean free environment for many, many reasons. I am coming from the side of creating an environment to make the treatment as beneficial as possible.

    I would like to get your observation on this topic, PLEASE.

    It seems like from viewing noted scientist presentation’s at Harvard and other information, that a technology (old and new [increasing like crazy] could be somehow affecting our bodies and for reasons (powers that be) NOT MUCH is being done about it. But some countries and institutions are.

    Could this somehow be a factor? I am trying to do the best I can for our son.

    Warm thanks on your help and feedback

    • EMF (mostly microwave energy generated by cell phones, phone towers and internal WiFi in your home) are so prevalent today it is very challenging to eliminate. Some things you can do to reduce that is to not use wireless phone in your home, turn off your WiFi at bedtime and don’t let your phone push emails.

  9. Mercury the road of ever more (Not much of a blessing to me)
    Mercury is a toll road with stops along the way You rush along this turnpike just to stop and pay When you think that surely you’ve paid enough to ride There comes another toll booth along there on the side You hear your young one sobbing screams from his restraints But you need to keep on going ignore his sad complaints Up ahead a hand is out someone else to pay No time for you to stop and rest along this sad highway written by: A Mercury Mom

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