News: Study Demonstrates the Beneficial Effects of Hyperbaric Oxygen on Vascular Cells
March 6, 2011 1 Comment
On February 28, 2011, researcher from the UK released a very interesting lab study. I am including an excerpt below.
Limited DNA damage in human endothelial cells after hyperbaric oxygen treatment and protection from subsequent hydrogen peroxide exposure.
Biochim Biophys Acta. 2011 Feb 28. [Epub ahead of print]
Yuan J, Handy RD, Moody AJ, Smerdon G, Bryson P.
School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK, PL4 8AA.
Conclusion: A single HBO exposure causes limited DNA damage to HUVECs (human blood vessel cells), which repairs quickly. HBO treatment protects against hydrogen peroxide-induced DNA damage and involves cellular glutathione (raises glutathione).
This group exposed cells to 2.2 ATA at 100% for 90 minutes in cell culture. Now that is not exactly the conditions cells have in a living organism. All the same if they can tolerate these stressful conditions and actually see benefits it is likely the human response would be even more robust.
I like the enhancement of glutathione they observed by the following day. Glutathione is the main cell defense against oxidative stress. Deficiencies of glutathione have been observed in autism, Parkinsonism, Alzheimer’s dementia and schizophrenia. Using pulses of HBO to increase glutathione response is logical in these conditions.
These observations may also explain why HBO improves stem transplanting as well. We previously discussed on this blog the observations of significant combined effects of HBO and Stem Cells on cardiac regeneration.